脂肪细胞的分化形成与天然产物调控

doi:10.12160/j.issn.1672-5190.2020.04.004

Abstract

Abstract: The elucidation of fat synthesis mechanisms and related regulative process is meaningful for preventing and curing a variety of obesity-associated diseases, ameliorating meat flavor and quality, and improving livestock production efficiency. Adipocytes originate from pluripotent mesenchymal stem cells （MSCs） in bone marrow. After receiving extracellular stimulating factors, they quickly induce the expression of early fat regulatory factors, C/EBPβ and C/EBPδ, and transmit information to PPARγ, C/EBPα and other transcription factors that promote cells differentiation and lipid droplets formation. There are varieties of transcription factors and cyclins involved in the process of differentiation of pre-adipocytes to adipocytes and adipogenesis. Studies have shown that some natural organic compounds derived from plants, such as polyphenols, alkaloids, terpenes and quinones, play important regulative roles in differentiation of adipocytes and inhibition of adipogenesis. More investigations on natural products must be done before developing medicines treatment for obesity-associated diseases through suppression of lipid droplets accumulation in cells.

Key words: adipocytes, cell differentiation, transcription factors, natural organic compounds

CLC Number:

YIN Wei-wen, ZHANG Zhi-chao, WANG Xiao-qi, DUAN Zi-yuan. Differentiation and Formation of Adipocytes and Regulative Role of Natural Organic Compounds[J]. Animal Husbandry and Feed Science, 2020, 41(4): 17-27.

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References 105

[1]	FERNANDO I P S,RYU B,AHN G,et al. Therapeutic potential of algal natural products against metabolic syndrome: a review of recent developments[J].Trends in Food Science and Technology,2020,97:286-299.
[2]	KAHN R,BUSE J,FERRANNINI E,et al.The metabolic syndrome[J].Lancet,2005,366(9501):1921-1922.
[3]	HAUSMAN G J,BERGEN W G,ETHERTON T D,et al.The history of adipocyte and adipose tissue research in meat animals[J].Journal of Animal Science,2018,96(2):473-486.
[4]	LADEIRA M M,SCHOONMKER J P,SWANSON K C,et al.Nutrigenomics of marbling and fatty acid profile in ruminant meat[J].Animal,2018,12(S2):282-294.
[5]	WHEELER T L,CUNDIFF L V,KOCH R M.Effect of marbling degree on beef palatability in bos taurus and bos indicus cattle[J].Journal of Animal Science,1994,72(12):3145-3151.
[6]	PIAO M Y,BAIK M.Seasonal variation in carcass characteristics of Korean cattle steers[J].Asian-Australasian Journal of Animal Sciences,2015,28(3):442-450.
[7]	HUNT M R,GARMYN A J,O′QUINN T G,et al. Consumer assessment of beef palatability from four beef muscles from USDA choice and select graded carcasses[J].Meat Science,2014,98(1):1-8.
[8]	ADERLE E D,FORREST J C,CERRARD D E,et al.Principles of Meat Science [M].Dubuque:Kendall Hunt Publishing Company,2001.
[9]	PARK S J,BEAK S H,JUNG D J S,et al. Genetic, management, and nutritional factors affecting intramuscular fat deposition in beef cattle-A review[J].Asian-Australasian Journal of Animal Sciences,2018,31(7):1043-1061.
[10]	HUANG H Y,SONG T J,LI X,et al.BMP signaling pathway is required for commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage[J].Proceedings of the National Academy of Sciences of the United States of America,2009,106(31):12670-12675.
[11]	KAWAI M,ROSEN C J.The IGF-Ⅰ regulatory system and its impact on skeletal and energy homeostasis[J].Journal of Cellular Biochemistry,2010,111(1):14-19.
[12]	ZUÑIGA L A,SHEN W J,JOYCE-SHAIKH B,et al. IL-17 regulates adipogenesis, glucose homeostasis, and obesity[J].Journal of Immunology,2010,185(11):6947-6959.
[13]	WIDBRG C H,NEWELL F S,BACHMANN A W,et al.Fibroblast growth factor receptor 1 is a key regulator of early adipogenic events in human preadipocytes[J].American Journal of Physiology-Endocrinology and Metabolism,2009,296(1):121-131.
[14]	XIAO L P,SOBUE T,ESLIGER A,et al.Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells[J].Bone,2010,47(2):360-370.
[15]	ZARAGOSI L E,WDZIEKONSKI B,VILLAGEOIS P,et al.Activin a plays a critical role in proliferation and differentiation of human adipose progenitors[J].Diabetes,2010,59(10):2513-2521.
[16]	KAWAI M,NAMBA N,MUSHIAKE S,et al.Growth hormone stimulates adipogenesis of 3T3-L1 cells through activation of the Stat5A/5B-PPARγ pathway[J].Journal of Molecular Endocrinology,2007,38(1/2):19-34.
[17]	ROSEN E D,MACDOUGALD O A.Adipocyte differentiation from the inside out[J].Nature Reviews Molecular Cell Biology,2006,7(12):885-896.
[18]	WHITE U A,STEPHENS J M.Transcriptional factors that promote formation of white adipose tissue[J].Molecular and Cellular Endocrinology,2010,318(1/2):10-14.
[19]	JAMES D E,BROWN R,NAVARRO J,et al.Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein[J].Nature,1988,333(6169):183-185.
[20]	MESD J R,IRVINE S A,RAMJI D P.Lipoprotein lipase: structure, function, regulation, and role in disease[J].Journal of Molecular Medicine,2002,80(12):753-769.
[21]	SECKL J R,WALKER B R.11β-hydroxysteroid dehydrogenase type 1-A tissue-specific amplifier of glucocorticoid action[J].Endocrinology,2001,142(4):1371-1376.
[22]	SECKL J R.11β-Hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action?[J].Frontiers in Neuroendocrinology,1997,18(1):49-99.
[23]	ANAGNOSTIS P,ATHYROS V G,TZIOMALOS K,et al.The pathogenetic role of cortisol in the metabolic syndrome:A hypothesis[J].Journal of Clinical Endocrinology and Metabolism,2009,94(8): 2692-2701.
[24]	BAXA C A,SHA R S,BUELT M K,et al.Human adipocyte lipid-binding protein: purification of the protein and cloning of its complementary DNA[J].Biochemistry,1989,28(22): 8683-8690.
[25]	CHRISTIANSEN K,JENSEN P K.Membrane-bound lipid particles from beef heart. Chemical composition and structure[J]. Biochimica et Biophysica Acta,1972,260(3):449-459.
[26]	LASS A,ZIMMERMANN R,OBERER M,et al.Lipolysis—a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores[J].Progress in Lipid Research,2011,50(1):14-27.
[27]	GREGOIRE F M,SMAS C M,SUL S H.Understanding adipocyte differentiation[J].Physiological Reviews,1998,78(3):783-809.
[28]	WU Z,BUCHER N L,FARMER S R.Induction of peroxisome proliferator-activated receptor γ during the conversion of 3T3 fibroblasts into adipocytes is mediated by C/EBPβ, C/EBPδ, and glucocorticoids[J].Molecular and Cellular Biology,1996,16(8):4128-4136.
[29]	SUL H S,SMAS C,MEI B,et al.Function of pref-1 as an inhibitor of adipocyte differentiation[J].International Journal of Obesity and Related Metabolic Disorders,2000,24(S4):15-19.
[30]	CAO Z,UMEK R M,MCKNIGHT S L.Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells[J].Genes and Development,1991,5(9):1538-1552.
[31]	JIN S H,ZHAI B,QIU Z L,et al.c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process[J].The Journal of Biological Chemistry,2000,275(44):34344-34352.
[32]	ROSEN E D,SPIEGELMAN B M.Molecular regulation of adipogenesis[J].Annual Review of Cell and Developmental Biology,2000,16:145-171.
[33]	OTTO T C,LANE M D.Adipose development: from stem cell to adipocyte[J].Critical Reviews in Biochemistry and Molecular Biology,2005,40(4):229-242.
[34]	CHANG E,KIM C Y.Natural Products and Obesity: A focus on the regulation of mitotic clonal expansion during adipogenesis[J]. Molecules,2019,24(6):1157.
[35]	MACDOUGALD O A,MANDRUP S.Adipogenesis: forces that tip the scales[J].Trends in Endocrinology and Metabolism,2002,13(1):5-11.
[36]	WU J H,SRINIVASAN S V,NEUMANN J C,et al.The KLF2 transcription factor does not affect the formation of preadipocytes but inhibits their differentiation into adipocytes[J].Biochemistry,2005,44(33):11098-11105.
[37]	MEI B,ZHAO L,CHEN L,et al.Only the large soluble form of preadipocyte factor-1 (Pref-1), but not the small soluble and membrane forms, inhibits adipocyte differentiation: role of alternative splicing[J].Biochemical Journal,2002,364(1):137-144.
[38]	MOON Y S,SMAS C M,LEE K,et al.Mice lacking paternally expressed Pref-1/Dlk1 display growth retardation and accelerated adiposity[J].Molecular and Cellular Biology,2002,22(15):5585-5592.
[39]	TANG Q Q,LANE M D.Role of C/EBP homologous protein (CHOP-10) in the programmed activation of CCAAT/enhancer-binding protein-beta during adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2000,97(23): 12446-12450.
[40]	TONG Q,DALGIN G,XU H,et al.Function of GATA transcription factors in preadipocyte-adipocyte transition[J].Science,2000,290(5489):134-138.
[41]	ROSS S E,HEMATI N,LONGO K A,et al.Inhibition of adipogenesis by Wnt signaling[J].Science,2000,289(5481):950-953.
[42]	HUANG H Y,LANE M D,TANG Q Q.Effect of serum on the down-regulation of CHOP-10 during differentiation of 3T3-L1 preadipocytes[J].Biochemical and Biophysical Research Communications,2005,338(2):1185-1188.
[43]	TONTONOZ P,HU E,SPIEGELMAN B M.Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor[J].Cell,1994,79(7):1147-1156.
[44]	PAYNE V A,AU W S,LOWE C E,et al.C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis[J].Biochemical Journal,2009,425(1):215-223.
[45]	ZAGARIYA A,MUNGRE S,LOVIS R,et al.Tumor necrosis factor alpha gene regulation: enhancement of C/EBPβ-induced activation by c-Jun[J].Molecular and Cellular Biology,1998,18(5):2815-2824.
[46]	WU Z,ROSEN E D,BRUN R,et al.Cross-regulation of C/EBPα and PPARγ controls the transcriptional pathway of adipogenesis and insulin sensitivity[J].Molecular Cell,1999,3(2):151-158.
[47]	ROSEN E D,HSU C H,WANG X,et al.C/EBPα induces adipogenesis through PPARγ: a unified pathway[J].Genes and Development,2002,16(1):22-26.
[48]	LEFTEROVA M I,LAZAR M A.New developments in adipogenesis[J].Trends in Endocrinology and Metabolism,2009,20(3):107-114.
[49]	LONDOS C,BRASAEMLE D L,SCHULTZ C J,et al.Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells[J].Seminars in Cell and Developmental Biology,1999,10(1):51-58.
[50]	TANG Q Q,ZHANG J W,LANE M D.Sequential gene promoter interactions of C/EBPβ,C/EBPα,and PPARγ during adipogenesis[J].Biochemical and Biophysical Research Communications,2004,319(1):235-259.
[51]	KOERNER A,KRATZSCH J,KIESS W.Adipocytokines: leptin-the classical, resistin—the controversical, adiponectin-the promising, and more to come[J].Best Practice and Research Clinical Endocrinology and Metabolism,2005,19(4):525-546.
[52]	TANG Q Q,LANE M D.Activation and centromeric localization of CCAAT/enhancer-binding proteins during the mitotic clonal expansion of adipocyte differentiation[J].Genes and Development,1999,13(17):2231-2241.
[53]	PARK B H,QIANG L,FARMER S R.Phosphorylation of C/EBPβ at a consensus extracellular signal-regulated kinase/glycogen synthase kinase 3 site is required for the induction of adiponectin gene expression during the differentiation of mouse fibroblasts into adipocytes[J].Molecular and Cellular Biology,2004,24(19):8671-8680.
[54]	TANG Q Q,GRØNBORG M,HUANG H Y,et al. Sequential phosphorylation of CCAAT enhancer-binding protein beta by MAPK and glycogen synthase kinase 3β is required for adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(28):9766-9771.
[55]	KIM J W,TANG Q Q,LI X,et al.Effect of phosphorylation and S-S bond-induced dimerization on DNA binding and transcriptional activation by C/EBPβ[J].Proceedings of the National Academy of Sciences of the United States of America,2007,104(6):1800-1804.
[56]	TANG Q Q,OTTO T C,LANE M D.CCAAT/enhancer-binding protein β is required for mitotic clonal expansion during adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(3):850-855.
[57]	TANG Q Q,LANE M D.Adipogenesis: from stem cell to adipocyte[J].Annual Review of Biochemistry,2012,81:715-736.
[58]	SHAO D,LAZAR M A.Peroxisome proliferator activated receptor gamma, CCAAT/enhancer-binding protein α, and cell cycle status regulate the commitment to adipocyte differentiation[J].Journal of Biological Chemistry,1997,272(34):21473-21478.
[59]	DARLINGTON G J,WANG N,HANSON R W.C/EBPα: a critical regulator of genes governing integrative metabolic processes[J].Current Opinion in Genetics and Development,1995,5(5):565-570.
[60]	WU L W,GUO C Y,WU J Y.Therapeutic potential of PPARγ natural agonists in liver diseases[J].Journal of Cellular and Molecular Medicine,2020,24(5):2736-2748.
[61]	ZHAO L,YAGIZ Y,XU C,et al.Muscadine grape seed oil as a novel source of tocotrienols to reduce adipogenesis and adipocyte inflammation[J].Food and Function,2015,6(7):2293-2302.
[62]	CHRISTY R J,KAESTNER K H,GEIMAN D E,et al.CCAAT/enhancer binding protein gene promoter: binding of nuclear factors during differentiation of 3T3-L1 preadipocytes[J].Proceedings of the National Academy of Sciences of the United States of America,1991,88(6):2593-2597.
[63]	KOH Y K,LEE M Y,KIM J W,et al.Lipin1 is a key factor for the maturation and maintenance of adipocytes in the regulatory network with CCAAT/enhancer-binding protein α and peroxisome proliferator-activated receptorγ2[J].The Journal of Biological Chemistry,2008,283(50):34896-34906.
[64]	JONES J R,BARRICK C,KIM K A,et al.Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance[J].Proceedings of the National Academy of Sciences of the United States of America,2005,102(17):6207-6212.
[65]	REICHERT M,EICK D.Analysis of cell cycle arrest in adipocyte differentiation[J].Oncogene,1999,18(2):459-466.
[66]	TANG Q Q,OTTO T C,LANE M D.Mitotic clonal expansion: a synchronous process required for adipogenesis[J].Proceedings of the National Academy of Sciences of the United States of America,2003,100(1):44-49.
[67]	MOEEISON R F,FARMER S R.Role of PPARγ in regulating a cascade expression of cyclin-dependent kinase inhibitors, p18(INK4c)and p21(Waf1/Cip1), during adipogenesis[J].The Journal of Biological Chemistry,1999,274(24):17088-17097.
[68]	SHOBA G,JOY D,JOSEPH T,et al.Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers[J].Planta Medica,1998,64(4):353-356.
[69]	QIU Z,WEI Y,CHEN N,et al.DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes[J].The Journal of Biological Chemistry,2001,276(15):11988-11995.
[70]	KHALILPOURFARSHBAFI M,GHOLAMI K,MURUGAN D D,et al.Differential effects of dietary flavonoids on adipogenesis[J]. European Journal of Nutrition,2019,58(1):5-25.
[71]	HE J,GIUSTI M M.Anthocyanins: natural colorants with health-promoting properties[J].Annual Review of Food Science and Technology,2010,1:163-187.
[72]	GHOSH D,KONISHI T.Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function[J].Asia Pacific Journal of Clinical Nutrition,2007,16(2):200-208.
[73]	MATSUKAWA T,INAGUMA T,HAN J,et al.Cyanidin-3-glucoside derived from black soybeans ameliorate type 2 diabetes through the induction of differentiation of preadipocytes into smaller and insulin-sensitive adipocytes[J].Journal of Nutritional Biochemistry,2015,26(8):860-867.
[74]	POMPEI A,TONIATO E,INNOCENTI P,et al.Cyanidin reduces preadipocyte differentiation and relative ChREBP expression[J]. Journal of Biological Regulators and Homeostatic Agents,2012,26(2):253-264.
[75]	KIM H K,KIM J N,HAN S N,et al.Black soybean anthocyanins inhibit adipocyte differentiation in 3T3-L1 cells[J].Nutrition Research,2012,32(10):770-777.
[76]	SAKURAI N,MOCHIZUKI K,KAMEJI H,et al.(-)-Epigallocatechin gallate enhances the expression of genes related to insulin sensitivity and adipocyte differentiation in 3T3-L1 adipocytes at an early stage of differentiation[J].Nutrition,2009,25(10):1047-1056.
[77]	SHIN D W,KIM S N,LEE S M,et al.(-)-Catechin promotes adipocyte differentiation in human bone marrow mesenchymal stem cells through PPARγ transactivation[J].Biochemical Pharmacology,2009,77(1):125-133.
[78]	张宜楠,胡树清,杜志忠.高比功率复合电源[J].电源技术,2002(5):341-343.
[79]	ONO M,FUJIMORI K.Antiadipogenic effect of dietary apigenin through activation of AMPK in 3T3-L1 cells[J].Journal of Agricultural and Food Chemistry,2011,59(24):13346-13352.
[80]	HABINOWSKI S A,WITTERS L A.The effects of AICAR on adipocyte differentiation of 3T3-L1 cells[J]. Biochemical and Biophysical Research Communications,2001,286(5):852-856.
[81]	PARK U H,JEONG J C,JANG J S,et al.Negative regulation of adipogenesis by kaempferol, a component of Rhizoma Polygonati falcatum in 3T3-L1 cells[J].Biological and Pharmaceutical Bulletin,2012,35(9):1525-1533.
[82]	SHUKLA S,GUPTA S.Apigenin-induced cell cycle arrest is mediated by modulation of MAPK, PI3K-Akt, and loss of cyclin D1 associated retinoblastoma dephosphorylation in human prostate cancer cells[J].Cell Cycle,2007,6(9):1102-1114.
[83]	TAKAGAKI N,SOWA Y,OKI T,et al.Apigenin induces cell cycle arrest and p21/WAF1 expression in a p53-independent pathway[J].International Journal of Oncology,2005,26(1): 185-189.
[84]	LEE J,JUNG E,LEE J,et al.Isorhamnetin represses adipogenesis in 3T3-L1 cells[J].Obesity,2009,17(2):226-232.
[85]	FISCHER-POSOVSZKY P,KUKULUS V,TEWS D,et al.Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner[J].American Journal of Clinical Nutrition,2010,92(1):5-15.
[86]	LEE Y J,CHOI H S,SEO M J,et al.Kaempferol suppresses lipid accumulation by inhibiting early adipogenesis in 3T3-L1 cells and zebrafish[J].Food and Function,2015,6(8):2824-2833.
[87]	CHOI I,PARK Y,CHOI H,et al.Anti-adipogenic activity of rutin in 3T3-L1 cells and mice fed with high-fat diet[J].Biofactors,2006,26(4):273-281.
[88]	MANACH C,WILLIANSON G,MORAND C,et al.Bioavailability and bioefficacy of polyphenols in humans. Ⅰ. Review of 97 bioavailability studies[J].American Journal of Clinical Nutrition,2005,81(S1):230-242.
[89]	WANG H R,ZHU C,YING Y,et al.Metformin and berberine,two versatile drugs in treatment of common metabolic diseases[J].Oncotarget,2018,9(11):10135-10146.
[90]	HU Y S,DAVIES G E.Berberine inhibits adipogenesis in high-fat diet-induced obesity mice[J].Fitoterapia,2010,81(5):358-366.
[91]	TONG Q,TSAI J,TAN G,et al.Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation[J].Molecular and Cellular Biology,2005,25(2):706-715.
[92]	DAY C R,KEMPSON S A.Betaine chemistry, roles, and potential use in liver disease[J].Biochimica et Biophysica Acta,2016,1860(6):1098-1106.
[93]	XU G,HUANG K X,ZHOU J.Hepatic AMP kinase as a potential target for treating nonalcoholic fatty liver disease: Evidence from studies of natural products[J].Current Medicinal Chemistry,2018,25(8):889-907.
[94]	XU L,HUANG D H,HU Q L,et al.Betaine alleviates hepatic lipid accumulation via enhancing hepatic lipid export and fatty acid oxidation in rats fed with a high-fat diet[J].British Journal of Nutrition,2015,113(12):1835-1843.
[95]	LI S S,WANG H C,WANG X X,et al.Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig[J].Journal of Animal Science and Biotechnology,2017,8:72.
[96]	FEI Z W,QIU M K,QI X Q,et al.Oxymatrine suppresses proliferation and induces apoptosis of hemangioma cells through inhibition of HIF-1a signaling[J].International Journal of Immunopathology and Pharmacology,2015,28(2):201-208.
[97]	SHI L J,SHI L,ZHANG H F,et al.Oxymatrine ameliorates non-alcoholic fatty liver disease in rats through peroxisome proliferator-activated receptor-α activation[J].Molecular Medicine Reports,2013,8(2):439-445.
[98]	DEROSA G,MAFFIOLI P,SAHEBKAR A.Piperine and its role in chronic diseases[J].Advances in Experimental Medicine and Biology,2016,928:173-184.
[99]	PARK U H,JRONG H S,JO E Y,et al.Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARγ activity in 3T3-L1 cells[J].Journal of Agricultural and Food Chemistry,2012,60(15):3853-3860.
[100]	KIM K J,LEE M S,JO K,et al.Piperidine alkaloids from Piper retrofractum Vahl. protect against high-fat diet-induced obesity by regulating lipid metabolism and activating AMP-activated protein kinase[J].Biochemical and Biophysical Research Communications,2011,411(1):219-225.
[101]	JÄGER S,TROJAN H,KOPP T,et al.Pentacyclic triterpene distribution in various plants-rich sources for a new group of multi-potent plant extracts[J].Molecules,2009,14(6): 2016-2031.
[102]	LIU J.Oleanolic acid and ursolic acid: research perspectives[J].Journal of Ethnopharmacology,2005,100(1/2):92-94.
[103]	KUNKEL S D,EMORE C J,BONGERS K S,et al.Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease[J].PLoS One,2012,7(6):e39332.
[104]	ZHENG C D,DUAN Y Q,GAO J M,et al.Screening for anti-lipase properties of 37 traditional Chinese medicinal herbs[J].Journal of the Chinese Medical Association,2010,73(6):319-324.
[105]	ZHANG Y,FAN S J,HU N,et al.Rhein reduces fat eeight in db/db mouse and prevents diet-induced obesity in C57Bl/6 mouse through the inhibition of PPARγ signaling[J].PPAR Research,2012,2012:374936.

Differentiation and Formation of Adipocytes and Regulative Role of Natural Organic Compounds

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