间充质干细胞发挥抗菌作用的机制研究进展

doi:10.12160/j.issn.1672-5190.2022.02.004

Abstract

Abstract: The emergence of ′superbug′ with high antimicrobial resistance poses a serious threat to human and domestic animal health. The fundamental cause of ′superbug′ is extensive and high-frequency usage of limited categories of antimicrobial agents for the treatment of bacterial infectious diseases in humans, domestic animals, and pets. One of the hottest research areas right now is discovering alternatives or enhancers for existing conventional antibiotics. Researchers have found the antibacterial characteristics of mesenchymal stem cells （MSCs）. Theoretically, MSCs have the potential to be developed as an effective means for the treatment of bacterial infectious diseases. This paper reviews the research progress in the mechanisms underlying the effects of MSCs on bacterial survival and in the possible impacts of antibiotics on MSCs functions, in hoping to provide references for further clarifying the antibacterial action mechanisms of MSCs and exploring the potential of MSCs as a novel means for therapy of bacterial infectious diseases.

Key words: antimicrobial agent, mesenchymal stem cells, antibacterial action, cell therapy, immune regulation

CLC Number:

S852.2

LI Xiao-qi, WANG Feng-wu, HAN Jian-jian. Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells[J]. Animal Husbandry and Feed Science, 2022, 43(2): 23-27.

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Research Progress in the Mechanisms Underlying the Antibacterial Action of Mesenchymal Stem Cells

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