Animal Husbandry and Feed Science ›› 2023, Vol. 44 ›› Issue (2): 66-71.doi: 10.12160/j.issn.1672-5190.2023.02.011

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Research Progress of Hair Follicle Morphogenesis and Related Signaling Pathways in Mammals

GAO Yu,YIN Jun   

  1. Inner Mongolia Agricultural University,Hohhot 010018,China
  • Received:2023-01-11 Online:2023-03-30 Published:2023-05-10

Abstract:

The development of hair follicle structures is completed during the embryonic stage. It is a complex physiological process that is divided into 3 classical stages: induction, organogenesis and cell differentiation. Hair follicles are regulated by a variety of molecules during growth and development, involving complex signal cross talk at various stages of hair follicle development. Currently, many signaling pathways as well as the growth factors′ modes of action lack adequate and explicit elucidations. This paper reviews recent research on hair follicle morphogenesis in mammals and associated signaling pathways to better understand the signaling regulation mechanism of hair follicle growth. It also presents the basic structure of hair follicles, explains the division and corresponding characteristics of hair follicle development stages, and summarizes the Wnt signal, Eda signal, Fgf signal, Bmp signal, Shh signal, Pdgfa signal, Notch signal and some other signaling pathways involved in various stages of hair follicle development and their roles, in hoping to provide references for unravelling the pathogenesis of related cancers caused by certain signaling pathway defects.

Key words: hair follicle structure, morphogenesis, signaling regulation, mammal

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