定时输精技术在母猪批次化生产中的应用研究进展

doi:10.12160/j.issn.1672-5190.2026.02.010

Abstract

Abstract: In recent years, due to the dual effects of African swine fever and the COVID-19 epidemic, the pig breeding industry has been seriously affected. The batch production management model has been widely used in pig farms, which has greatly improved the efficiency of pig production. Timed artificial insemination is a key technology to realize batch production of sows and can effectively increase the annual number of farrowings per sow, save semen consumption, and simultaneously reduce the risk of disease transmission among pigs, thus showing broad application prospects. This paper reviews the commonly used hormones, technical applications, influencing factors, existing problems and corresponding solutions of timed artificial insemination in sows, aiming to provide technical references for the batch production mode of pig farms. Timed artificial insemination technology can be divided into simplified timed artificial insemination and precise timed artificial insemination. The former requires estrus detection and is easy to operate, while the latter does not require estrus detection and is more commonly used in batch production. The effectiveness of this technique is affected by factors such as semen quality, hormone quality and safety, the number of inseminations, and feeding management. At present, there are still problems such as high incidence of follicular cysts, high number of white stillborn piglets, and reduced farrowing rate in gilts. These problems can be improved through the establishment of puberty for gilts, optimization of hormone use, and precision feeding and management. In the future, the timed artificial insemination technology can be further improved by developing new semen extenders, optimizing insemination procedures, improving the accuracy of estrus and ovulation detection, developing new deep artificial insemination catheters, and enhancing hormone potency, thereby promoting the healthy development of batch production.

Key words: timed artificial insemination, sows, batch production, hormone

CLC Number:

S828.34

XIAO Haoqi, QU Yingxin, SHI Zhenping, ZHANG Jinwen, WU Xiaxia, MENG Meili, BAI Furong, BAI Jie. Research Progress on the Application of Timed Artificial Insemination Technology in Batch Production of Sows[J]. Animal Husbandry and Feed Science, 2026, 47(2): 72-78.

References

[1] DE RENSIS F, KIRKWOOD R N.Control of estrus and ovulation:fertility to timed insemination of gilts and sows[J].Theriogenology,2016,86(6):1460-1466.
[2] 程玲华,安磊,李琴,等.同期排卵-定时输精技术提升非洲猪瘟疫情下三元母猪利用率的效果[J].今日养猪业,2022(6):87-89.
[3] 程玲华,白佳桦,崔健,等.同期排卵-定时输精程序对后备母猪繁殖性能的影响[J].中国畜牧杂志,2022,58(8):235-242.
[4] 杨小伟,刘玉,王国琪.定时输精技术对后备母猪繁殖性能的影响[J].国外畜牧学(猪与禽),2022,42(3):49-51.
[5] 闻爱友,胡洪,吴学壮,等.精准定时输精对夏季母猪繁殖性能的影响[J].安徽科技学院学报,2022,36(3):1-4.
[6] 朱志伟,陈晓宇,于福先,等.精准定时输精对后备母猪早期胚胎发育与繁殖性能的影响[J].浙江农业学报,2021,33(5):794-800.
[7] 李晗星,齐雅天,刘明智,等.猪卵泡发育特征及影响因素的研究进展[J].中国畜牧杂志,2022,58(3):48-51.
[8] SCHWARZ T, KOPYRA M, NOWICKI J.Physiological mechanisms of ovarian follicular growth in pigs:a review[J].Acta Veterinaria Hungarica,2008,56(3):369-378.
[9] PELUSO J J.Progesterone signaling and mammalian ovarian follicle growth mediated by progesterone receptor membrane component family members[J].Cells,2022,11(10):1632.
[10] KHODADADI A, NIASARI-NASLAJI A, NIKJOU D, et al.Superovulation of high-producing Holstein lactating dairy cows with human recombinant FSH and hMG[J].Theriogenology,2022,191:239-244.
[11] HERBISON A E.A simple model of estrous cycle negative and positive feedback regulation of GnRH secretion[J].Frontiers in Neuroendocrinology,2020,57:100837.
[12] STELLETTA C, TEKIN K, TIRPAN M B, et al.Vulvar thermal pattern following synchronization of estrus is linked to fertility after timed artificial insemination in goat[J].Theriogenology,2017,103:137-142.
[13] WANG Z, LIU B S, WANG X Y, et al.Effects of altrenogest on reproductive performance of gilts and sows:a meta-analysis[J].Animal Reproduction Science,2018,197:10-21.
[14] HERNÁNDEZ-CARAVACA I, IZQUIERDO-RICO M J, MATÁS C, et al. Reproductive performance and backflow study in cervical and post-cervical artificial insemination in sows[J].Animal Reproduction Science,2012,136(1/2):14-22.
[15] 唐斯嘎,韩乌兰图雅,娜仁花,等.人绒毛膜促性腺激素对母驴促排卵效果的研究[J].畜牧与饲料科学,2021,42(3):59-65.
[16] THENNATI R, SINGH S, NAGE N, et al.Analytical characterization of recombinant hCG and comparative studies with reference product[J].Biologics:Targets and Therapy,2018,12:23-35.
[17] 王燕春,崔贞亮.定时输精前15天给予马绒毛膜促性腺激素可提高后备母猪的繁殖性能[J].猪业科学,2022,39(5):26-30.
[18] KNOX R V, WEBEL S K, SWANSON M, et al.Effects of estrus synchronization using Matrix® followed by treatment with the GnRH agonist triptorelin to control ovulation in mature gilts[J].Animal Reproduction Science,2017,185:66-74.
[19] ZIECIK A J, KLOS J, GROMADZKA-HLIWA K, et al.Endocrine and molecular milieus of ovarian follicles are diversely affected by human chorionic gonadotropin and gonadotropin-releasing hormone in prepubertal and mature gilts[J].Scientific Reports,2021,11:13465.
[20] BREEN S M, RODRIGUEZ-ZAS S L, KNOX R V. Effect of altering dose of PG600 on reproductive performance responses in prepubertal gilts and weaned sows[J].Animal Reproduction Science,2006,95(3/4):316-323.
[21] 王学文,吴凤霞,杨颜,等.烯丙孕素和PG600对后备母猪繁殖性能的影响[J].猪业科学,2021,38(12):98-100.
[22] HABEEB H M H, HAZZARD T M, STORMSHAK F, et al. Effect of different dosages of PG-600 on ovulation and pregnancy rates in ewes during the breeding season[J].Translational Animal Science,2019,3(1):429-432.
[23] 李晓,董瑞兰,宋春阳,等.烯丙孕素对批次化生产中后备母猪繁殖性能及后代生长性能的影响[J].中国畜牧杂志,2020,56(11):171-174,178.
[24] KNOX R V, STEWART K R, FLOWERS W L, et al.Design and biological effects of a vaginally administered gel containing the GnRH agonist, triptorelin, for synchronizing ovulation in swine[J].Theriogenology,2018,112:44-52.
[25] ULGUIM R R, FONTANA D L, BERNARDI M L, et al.Single fixed-time artificial insemination in gilts and weaned sows using pLH at estrus onset administered through vulvar submucosal route[J].Theriogenology,2016,86(4):1072-1080.
[26] MCBRIDE M, AMEZCUA R, CASSAR G, et al.Combining fixed-time insemination and improved catheter design in an effort to improve swine reproduction efficiency[J].Animals,2019,9(10):748.
[27] 卓卫杰. 催产素在母猪生产中的应用[J].江西饲料,2019(6):9-10,14.
[28] 朱雪丹,潘学情,马君艳,等.前列腺素F2a及其类似物对哺乳动物生殖影响的研究进展[J].中国畜牧兽医,2022,49(8):3072-3082.
[29] PUNETHA M, KUMAR S, PAUL A, et al.Deciphering the functional role of EGR1 in Prostaglandin F₂ alpha induced luteal regression applying CRISPR in corpus luteum of buffalo[J].Biological Research,2021,54:9.
[30] TUMMARUK P, SANG-GASSANEE K, AUDBAN C, et al.Gilt reproductive performance in a tropical environment after Oestrus synchronization and fixed-time artificial insemination[J].Theriogenology,2022,192:45-51.
[31] SPENCER K W, PURDY P H, BLACKBURN H D, et al.Effect of number of motile, frozen-thawed boar sperm and number of fixed-time inseminations on fertility in estrous-synchronized gilts[J].Animal Reproduction Science,2010,121(3/4):259-266.
[32] DRIANCOURT M A, COX P, RUBION S, et al.Induction of an LH surge and ovulation by buserelin (as Receptal) allows breeding of weaned sows with a single fixed-time insemination[J].Theriogenology,2013,80(4):391-399.
[33] PEARODWONG P, TRETIPSKUL C, PANYATHONG R, et al.Reproductive performance of weaned sows after single fixed-time artificial insemination under a tropical climate: Influences of season and insemination technique[J].Theriogenology,2020,142:54-61.
[34] SUÁREZ-USBECK A, MITJANA O, TEJEDOR M T, et al. Single fixed-time post-cervical insemination in gilts with buserelin[J].Animals,2021,11(6):1567.
[35] MARTINAT-BOTTÉ F, VENTURI E, GUILLOUET P, et al.Induction and synchronization of ovulations of nulliparous and multiparous sows with an injection of gonadotropin-releasing hormone agonist (Receptal)[J].Theriogenology,2010,73(3):332-342.
[36] 范玉珊,吴俊辉,高凤磊,等.定时输精对经产母猪繁殖性能及生殖激素的影响[J].中国畜牧兽医,2021,48(10):3726-3733.
[37] BELSTRA B A, WILLENBURG K L, GÓMEZ-LÓPEZ D H, et al. Effects of the number of sperm and site of uterine semen deposition on conception rate and the number of embryos in weaned sows receiving a single fixed-time insemination[J].Journal of Animal Science,2020,98(9):skaa260.
[38] DA ROSA ULGUIM R, WILL K J, MELLAGI A P, et al. Does a single fixed-time insemination in weaned sows affect gestation and lactation length, and piglet performance during lactation compared with multiple insemination protocols in a commercial production setting?[J].Animal Reproduction Science,2022,247:107072.
[39] FENG C W, ZHU Z D, BAI W J, et al.Proline protects boar sperm against oxidative stress through proline dehydrogenase-mediated metabolism and the amine structure of pyrrolidine[J].Animals,2020,10(9):1549.
[40] HENSEL B, JAKOP U, SCHEINPFLUG K, et al.Low temperature preservation of porcine semen: Influence of short antimicrobial lipopeptides on sperm quality and bacterial load[J].Scientific Reports,2020,10:13225.
[41] KUSTER C E, ALTHOUSE G C.The impact of bacteriospermia on boar sperm storage and reproductive performance[J].Theriogenology,2016,85(1):21-26.
[42] SHAOYONG W, LI Q, REN Z Q, et al.Effects of kojic acid on boar sperm quality and anti-bacterial activity during liquid preservation at 17 C[J].Theriogenology,2019,140: 124-135.
[43] SCHULZE M, AMMON C, SCHAEFER J, et al.Impact of different dilution techniques on boar sperm quality and sperm distribution of the extended ejaculate[J].Animal Reproduction Science,2017,182:138-145.
[44] RECUERO S, FERNANDEZ-FUERTES B, BONET S, et al.Potential of seminal plasma to improve the fertility of frozen-thawed boar spermatozoa[J].Theriogenology,2019,137: 36-42.
[45] 吴俊辉,高凤磊,卫恒习,等.猪场批次化生产模式和激素的选择[J].猪业科学,2020,37(4):40-42.
[46] 刘闯,李楠,白佳桦,等.母猪定时输精常用激素与应用效果的研究进展[J].今日养猪业,2019(4):33-37.
[47] BORTOLOZZO F P, UEMOTO D A, BENNEMANN P E, et al.Influence of time of insemination relative to ovulation and frequency of insemination on gilt fertility[J].Theriogenology,2005,64(9):1956-1962.
[48] ZIECIK A J, KLOS J, PRZYGRODZKA E, et al.Aberrant effects of altrenogest and exposure to exogenous gonadotropins on follicular cysts appearance in gilts[J].Theriogenology,2017,89: 250-254.
[49] 李智,刘彦,白佳桦,等.批次化生产与定时输精对母猪利用率的影响[J].猪业科学,2021,38(6):110-112.
[50] ZHANG L W, GUO X, ZHANG W. Nutrients and pheromones promote insulin release to inhibit courtship drive[J].Science Advances,2022,8(10):eabl6121.
[51] WANG Z, LIU B S, WANG X Y, et al.Effects of fixed-time artificial insemination using triptorelin on the reproductive performance of pigs:a meta-analysis[J].Animal,2020,14(7):1481-1492.
[52] KNOX R V, ESPARZA-HARRIS K C, JOHNSTON M E, et al. Effect of numbers of sperm and timing of a single, post-cervical insemination on the fertility of weaned sows treated with OvuGel®[J].Theriogenology,2017,92:197-203.
[53] WANG Z, LIU B S, WANG X Y, et al.Effects of fixed-time artificial insemination using triptorelin on the reproductive performance of pigs:a meta-analysis[J].Animal, 2020, 14(7):1481-1492.

Research Progress on the Application of Timed Artificial Insemination Technology in Batch Production of Sows

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