Abstract: The epidemiological investigation on PPV disease was performed among 1 520 pregnant sows of 21 intensive pig farms of 6 cities （counties） with different geographic environments of Xuancheng City in Anhui Province by the writer. Among them, the reproductive handicap syndrome occurred on 671 sows, which accounted for 44.1%.The 1 520 pregnant sows produced 7 799 piglets, among which the 1 530 piglets were dead and the dead piglets accounted for 19.6 % in the total piglets. Among 671 pregnant sows with reproductive handicap syndrome, 207 shares of serum were sampled for serologic examination on PPV, Cp, Br and JEV. Among them, the positive response of antibody to PPV was up to 79.8 %. The study results indicated that the main cause of reproductive handicap syndrome was PPV infection in the city. So, the main object of preventing reproductive handicap syndrome should be transferred from Br disease to PPV disease and the periodic monitorring system of antibody in serum of pig group should be set up to strengthen the epidemic prevention of PPV disease.