Abstract: In order to establish rapid testing methods for piglets eperythrozoonosis, pathological anatomy and pathohistology was applied to examine piglets suffering from eperythrozoonsis in this experiment. The results indicated that it caused cell degeneration and necrosis in liver, spleen, lymph node of piglet infected with Eperythrozoon, meanwhile also a lot of red cells splintered. The conclusion could be made that massive destruction of red blood cells and liver, cell degeneration of spleen and lymph node and necrosis is the main cause of the deaths of piglets.