Abstract: In the study,8 week-old ICR mice were selected as the experimental object.The trial animals were fed with different concentration sucrose under long-term stimulation,then they were killed by nitrogen,duodena were obtained,immunohistochemistry method was applied to detect villus shape and the expression level of α-gustducin,meanwhile blood sugar concentration change of mice also was determined intragastric administration before and afterwards.The result showed that rate of duodena velvet rise with the increase of sugar concentration,but there was no significant change in expression of α-gustducin.The conclusion could be made that with stimulation prolongation,the ability of tolerance to sugar enhancement.