Abstract: Oxidative stress injury is considered to be closely associated with development of a variety of diseases in the body.When oxidative stress is severe, the inhibiting of oxidative stress and scavenging of oxygen free radical can be served as an important strategy for treatment of related diseases. Nrf2-ARE signaling pathway is an extremely important endogenous defense system in the body, which can maintain the balance of redox state in the cell and reduce the injuries produced by oxidative stress by regulating Nrf2-ARE signaling pathways. The role of Nrf2-ARE pathway in regulating antioxidant enzymes activity, the association of Nrf2-ARE pathway with the emergence of oxidative stress related diseases, and the relationship of Nrf2-ARE pathway with other signaling pathways were reviewed in this article, so as to provide a reference for a better understanding of the role of Nrf2-ARE signaling pathway in resisting oxidation stress injury in the body as well as of related mechanisms.