Abstract: Urinary closure is a commonly observed urologic disease in cats. This disease is usually caused by lower urinary tract syndrome （spontaneous cystitis） and bladder stones. There is higher risk for male cats for this disease due to their special anatomical structure. Urinary closure always results in acute renal failure. Here, we introduces the clinical diagnosis, laboratory diagnosis and treatment of a case of acute renal failure in cat caused by urinary closure with emphasis on treatment protocols, so as to provide references for other pet veterinarians.