Abstract: The aim of this research was to study the expression of KAP6 gene family on the skins follicle of fetal inner mongolia arbas white cashmere goat. In the present study, the gigoxin （DIG）labeled cRNA of arbas white cashmere goat KAP6 gene family was synthesized in vitro and was used to localize in the skin slice of fetal goat by chromosomal in situ hybridization technique, so as to detect KAP6 mRNA in the skin tissues of cashmere goat during embryonic period. The results showed that a strong signal in the cortex layer of both primary and secondary hair follicles was expressed. Therefore, KAP6 is the component of wool and cortex protein of cashmere and an important protein, which play a role of keratinization in cortical layer, directly involved in the synthesis of cashmere and coarse wool and affected the physico-ehemieal property of pelage.