Animal Husbandry and Feed Science ›› 2010, Vol. 31 ›› Issue (11): 20-20.doi: 10.12160/j.issn.1672-5190.2010.11.009

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Molecular Mechanisms of Maintaining Self-renewal of Embryonic Stem Cell

ZHU Tie-gang,LIU Li,WANG Gui-feng (1.College of Life Science,Hengshui University,Hengshui 053000,China;2.Department of Animal Sciences,Langfang Polytechnic Institute,Langfang 065000,China;3.Agricultural Bureau of Hengshui City,Hengshui 053000,China)   

  • Online:2010-11-20 Published:2010-11-20

Abstract: Regulation of self-renewal of embryonic stem cells(ES) is a complex molecular signaling system.When the signal system is in overall balance,the self-renewal of ES cells can be maintained.The ES cells can be applied and the downstream stem cell-based technology can be developed only after the function of these signaling pathways has been understood.The paper reviews the research progress in the molecular mechanism of self-renewal of ES cells by analyzing important cytokines such as LIF,Oct-4 and Nanog.

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