Abstract: Streptococcus suis type 2 （SS2） is an important zoonosis pathogen, which can cause a variety of serious diseases in swine and human. The classic virulence factors of SS2 include capsular antigen, lysozyme released protein, hemolysin etc. In recent years, some new genes or components related to pathogenicity and virulence, and some proteases were found in SS2. The virulence factors mostly have good immunogenicity and play important role in pathogenicity and growth progress of Streptococcs sp.. Some immunogenic virulence factors by SS2 can be generated as recombinant proteins in vitro. These recombinant proteins are expected to produce gene engineering vaccines for effective preventing SS2 infection.