异荭草素抗肿瘤药理作用及其机制的研究

doi:10.12160/j.issn.1672-5190.2019.09.018

畜牧与饲料科学 ›› 2019, Vol. 40 ›› Issue (9): 86-88.doi: 10.12160/j.issn.1672-5190.2019.09.018

异荭草素抗肿瘤药理作用及其机制的研究

张彤, 张宇, 王诗浓, 王加茹, 罗英花, 金成浩

黑龙江八一农垦大学生命科学技术学院,黑龙江大庆 163319

收稿日期:2019-04-28 出版日期:2019-09-30 发布日期:2019-12-17
通讯作者: 金成浩（1977—）,男,教授,博士（后）,主要从事癌症发病机理研究及新药研发工作。
作者简介:张彤（1998—）,女,所学专业为制药工程。
基金资助:
黑龙江省科学基金项目（LC2015036）; 黑龙江省博士后科研启动自足项目（LBH-Q13132）

Research Progress on Anti-tumor Pharmacological Effects and Mechanism of Isoorientin

ZHANG Tong, ZHANG Yu, WANG Shi-nong, WANG Jia-ru, LUO Ying-hua, JIN Cheng-hao

College of Life Science and Technology,Heilongjiang Bayi Agricultural University,Daqing 163319, China

Received:2019-04-28 Online:2019-09-30 Published:2019-12-17

摘要/Abstract

摘要： 异荭草素是从植物中提取的含有黄酮类活性成分的化合物。研究表明,异荭草素具有多种药理作用,不仅可以抗氧化、抗炎、抗病毒,还具有良好的抗肿瘤活性。异荭草素可通过干扰肿瘤细胞增殖、诱导肿瘤细胞凋亡、调控活性氧水平、诱导肿瘤细胞自噬、阻碍肿瘤细胞浸润和转移等途径发挥抗肿瘤作用。现将异荭草素的抗肿瘤作用及其机制的相关研究进展进行综述。

关键词: 异荭草素, 抗肿瘤, 细胞凋亡, 细胞自噬, 细胞增殖

Abstract: Isoorientin is a compound containing flavonoid active ingredients extracted from plants. Studies have shown that isoorientin has a variety of pharmacological effects, not only has antioxidant, anti-inflammatory and anti-viral activities, but also has good anti-tumor activity. Isoorientin exerts anti-tumor role by interfering with the proliferation of cancer cells, inducing apoptosis of cancer cells, regulating the level of reactive oxygen species, inducing autophagy of cancer cells, and hindering the invasion and metastasis of cancer cells. This article reviewed the research progress of anti-tumor effect and mechanism of isoorientin.

Key words: isoorientin, anti-tumor, cell apoptosis, cell autophagy, cell proliferation

中图分类号:

R282.71

张彤, 张宇, 王诗浓, 王加茹, 罗英花, 金成浩. 异荭草素抗肿瘤药理作用及其机制的研究[J]. 畜牧与饲料科学, 2019, 40(9): 86-88.

ZHANG Tong, ZHANG Yu, WANG Shi-nong, WANG Jia-ru, LUO Ying-hua, JIN Cheng-hao. Research Progress on Anti-tumor Pharmacological Effects and Mechanism of Isoorientin[J]. Animal Husbandry and Feed Science, 2019, 40(9): 86-88.

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异荭草素抗肿瘤药理作用及其机制的研究

Research Progress on Anti-tumor Pharmacological Effects and Mechanism of Isoorientin

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