哺乳动物毛囊形态发生及相关信号通路研究进展

doi:10.12160/j.issn.1672-5190.2023.02.011

摘要/Abstract

摘要：

毛囊结构的发育在胚胎期完成，是一个复杂的生理过程，被分为诱导、器官发生和细胞分化3个经典的阶段。毛囊在生长和发育过程中受到多种分子的调控，在毛囊发育各阶段都涉及复杂的信号互作，目前许多信号通路以及生长因子的作用方式还未得到有效、明确的阐述。为帮助理解毛囊生长的信号调控机制，对近年哺乳动物毛囊形态发生及相关信号通路研究的相关文献进行综述，介绍了毛囊的基本结构，阐述了毛囊发育阶段的划分及相应特征，综述了毛囊发育不同阶段涉及的Wnt信号、Eda信号、Fgf信号、Bmp信号、Shh信号、Pdgfa信号、Notch信号等相关信号通路及其发挥的作用，以期为解析由某些信号通路缺陷导致的相关癌症的发生机理提供参考。

关键词: 毛囊结构, 形态发生, 信号调控, 哺乳动物

Abstract:

The development of hair follicle structures is completed during the embryonic stage. It is a complex physiological process that is divided into 3 classical stages: induction, organogenesis and cell differentiation. Hair follicles are regulated by a variety of molecules during growth and development, involving complex signal cross talk at various stages of hair follicle development. Currently, many signaling pathways as well as the growth factors′ modes of action lack adequate and explicit elucidations. This paper reviews recent research on hair follicle morphogenesis in mammals and associated signaling pathways to better understand the signaling regulation mechanism of hair follicle growth. It also presents the basic structure of hair follicles, explains the division and corresponding characteristics of hair follicle development stages, and summarizes the Wnt signal, Eda signal, Fgf signal, Bmp signal, Shh signal, Pdgfa signal, Notch signal and some other signaling pathways involved in various stages of hair follicle development and their roles, in hoping to provide references for unravelling the pathogenesis of related cancers caused by certain signaling pathway defects.

Key words: hair follicle structure, morphogenesis, signaling regulation, mammal

中图分类号:

高宇, 尹俊. 哺乳动物毛囊形态发生及相关信号通路研究进展[J]. 畜牧与饲料科学, 2023, 44(2): 66-71.

GAO Yu, YIN Jun. Research Progress of Hair Follicle Morphogenesis and Related Signaling Pathways in Mammals[J]. Animal Husbandry and Feed Science, 2023, 44(2): 66-71.

图/表 1

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