附睾中非编码小RNA（sncRNA）的研究进展

doi:10.12160/j.issn.1672-5190.2023.02.010

畜牧与饲料科学 ›› 2023, Vol. 44 ›› Issue (2): 61-65.doi: 10.12160/j.issn.1672-5190.2023.02.010

附睾中非编码小RNA（sncRNA）的研究进展

许娇霞¹,张家新²,周璇¹,何小龙¹

1.内蒙古自治区农牧业科学院，内蒙古呼和浩特 010031
2.内蒙古农业大学动物科学学院/内蒙古自治区动物遗传育种与繁殖重点实验室，内蒙古呼和浩特 010018

收稿日期:2023-01-31 出版日期:2023-03-30 发布日期:2023-05-10
通讯作者: 何小龙（1983—），男，研究员，博士，硕士生导师，主要研究方向为绵羊遗传育种与繁殖。
作者简介:许娇霞（1997—），女，研究实习员，硕士研究生，主要研究方向为绵羊遗传育种与繁殖。
基金资助:
内蒙古自治区科技计划项目(2021GG0012);内蒙古自治区“揭榜挂帅”项目(2022JBGS0012)

Research Progress of Small Non-coding RNA（sncRNA）in Epididymis

XU Jiaoxia¹,ZHANG Jiaxin²,ZHOU Xuan¹,HE Xiaolong¹

1. Inner Mongolia Academy of Agricultural and Animal Husbandry Science，Hohhot 010031，China
2. College of Animal Science，Inner Mongolia Agricultural University/Inner Mongolia Key Laboratory of Animal Genetics，Breeding and Reproduction，Hohhot 010018，China

Received:2023-01-31 Online:2023-03-30 Published:2023-05-10

摘要/Abstract

摘要：

非编码小RNA（sncRNA）主要通过抑制性调控靶基因发挥作用。近年的研究发现sncRNA在哺乳动物附睾的各个部位均有表达，并且在调控附睾不同节段的基因表达方面起着非常关键的作用。附睾上皮细胞中sncRNA的多样性及其表达水平的时空差异会影响很多潜在的靶基因，从而调节附睾的生理功能，另外，这些sncRNA还可以通过附睾小体传递给精子，对精子产生一系列的调控作用。综述了附睾中sncRNA表达、sncRNA对附睾和附睾中精子功能调节方面的研究进展，以期为探究sncRNA对雄性生殖细胞调控作用的分子机制提供参考。

关键词: 非编码小RNA, 靶基因, 附睾, 附睾小体, 精子

Abstract:

Small non-coding RNA （sncRNA） functions primarily through inhibitory regulation of target genes. Recent research revealed that sncRNA is expressed in various parts of the mammalian epididymis and plays a crucial role in regulating gene expression in different segments of the epididymis. The diversity of sncRNA identified in epididymal epithelial cells and the spatiotemporal variations in sncRNA expression level may have an impact on many potential target genes, regulating the physiological functions of epididymis. In addition, these sncRNA can also be transmitted to sperm through epididymosomes, producing a series of regulatory effects on sperm. This paper reviews the research progress of the expression of sncRNA in epididymis as well as the regulation of sncRNA on epididymis function and sperm function in epididymis, in hoping to provide references for exploring the molecular mechanism of the regulatory effect of sncRNA on male germ cells.

Key words: small non-coding RNA, target gene, epididymis, epididymosomes, sperm

中图分类号:

Q78
Q492.4

许娇霞, 张家新, 周璇, 何小龙. 附睾中非编码小RNA（sncRNA）的研究进展[J]. 畜牧与饲料科学, 2023, 44(2): 61-65.

XU Jiaoxia, ZHANG Jiaxin, ZHOU Xuan, HE Xiaolong. Research Progress of Small Non-coding RNA（sncRNA）in Epididymis[J]. Animal Husbandry and Feed Science, 2023, 44(2): 61-65.

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附睾中非编码小RNA（sncRNA）的研究进展

Research Progress of Small Non-coding RNA（sncRNA）in Epididymis

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