动物冷应激相关蛋白和分子的最新研究进展

doi:10.12160/j.issn.1672-5190.2023.05.004

摘要/Abstract

摘要：

恒定的体温是维持生命活动的重要基础，恒温动物需要内源性产热源。寒冷条件下动物体温降低的直接后果是细胞内整体水平上蛋白质的合成被抑制，但冷诱导RNA结合蛋白（cold-inducible RNA binding protein，CIRP）、RNA结合基序蛋白3（RNA-binding motif protein 3，RBM3）、解偶联蛋白（uncoupling protein，UCP）、热休克蛋白（heat shock proteins，HSPs）以及少数细胞因子的表达却增加，从而确保细胞在寒冷环境中的内稳态和生存。对冷应激条件下动物体内被激发的蛋白及相关分子的最新研究进展进行综述，以期为冷应激蛋白分子领域的深入研究提供借鉴。

关键词: 产热, 冷应激, 哺乳动物, 细胞凋亡, 冷应激蛋白

Abstract:

Constant body temperature is crucial for maintaining life activities. Homeostatic animals require endogenous heat sources. The direct consequence of hypothermia in animals under cold conditions is the inhibition of protein synthesis at the overall cellular level, while the expressions of cold-inducible RNA binding protein （CIRP）, RNA-binding motif protein 3 （RBM3）, uncoupling protein （UCP）, heat shock proteins （HSPs） and a few cytokines are elevated, which ensures the homeostasis and survival of cells in cold environments. This paper summarizes the recent research progress on cold-inducible proteins and related molecules in animals, in hoping to provide insights into the in-depth research of cold-inducible proteins.

Key words: heat production, cold stress, mammal, apoptosis, cold-inducible protein

中图分类号:

S852.2
Q494

王燕琴, 孟宁生, 韩娜, 智宇. 动物冷应激相关蛋白和分子的最新研究进展[J]. 畜牧与饲料科学, 2023, 44(5): 22-29.

WANG Yanqin, MENG Ningsheng, HAN Na, ZHI Yu. Recent Advances in Cold-inducible Proteins and Related Molecules in Animals[J]. Animal Husbandry and Feed Science, 2023, 44(5): 22-29.

图/表 2

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