畜牧与饲料科学 ›› 2010, Vol. 31 ›› Issue (2): 22-22.doi: 10.12160/j.issn.1672-5190.2010.02.009
• 基础科学 • 上一篇 下一篇
杨晓娟 常城
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YANG Xiao-juan,CHANG Cheng(College of Life Science,Lanzhou University,Lanzhou 730000,China)
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摘要: 死亡受体6(death receptor 6,DR6)是肿瘤坏死因子受体超家族中的成员。DR6是Ⅰ型跨膜受体,拥有4个胞外半胱氨酸基序和1个胞内死亡结构域。在人的大多数组织表达中,已经发现其在心、脑、胎盘、胰脏、胸腺、淋巴结和几个非淋巴癌细胞系中表达。DR6可以和TRADD相互作用,激活JNK和NF-κB途径。DR6能下调T、B细胞的增殖和活化,诱导神经细胞的凋亡等。
Abstract: Death receptor 6(DR6 or TNFRSF21)is a member of TNF receptor superfamily.DR6 is a type-Ⅰtrans-membrane receptor possessing four extra -cellular cysteinerich motifs and a cytoplasmic death domain.DR6 is expressed in most human tissues and abundant transcript can be detected in heart,brain,placenta,pancreas,thymus,lymph node and several non-lymphoid cancer cell lines.DR6 can interact with TRADD and active both JNK and NF-κB.In addition,DR6 inhibits proliferation and activation of T and B cell,and it also involved in inducing neurons cell apoptosis.
中图分类号:
Q786
杨晓娟,常城. 死亡受体6的作用机制及其生物学功能[J]. 畜牧与饲料科学, 2010, 31(2): 22-22.
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