畜牧与饲料科学 ›› 2011, Vol. 32 ›› Issue (5): 5-5.doi: 10.12160/j.issn.1672-5190.2011.05.003

• 基础科学 • 上一篇    下一篇

右旋糖酐微量元素络合物合成及其对小鼠生长的影响

郭丽华 刘在青 肖建森 李莎   

  1. 山东德州神牛药业有限公司,山东德州253034
  • 出版日期:2011-05-20 发布日期:2011-05-20
  • 通讯作者: 郭丽华
  • 作者简介:郭丽华(1980-),女,药师,主要从事药物制剂生产和工艺研究工作。

Synthesis of Dextran Trace Elements Complex and Its Effects on the Growth of Mice

GUO Li-hua,LIU Zai-qing,XIAO Jian-sen,LI Sha (Shandong Dezhou Shenniu Pharmaceutical Limited Company,Dezhou 253034,China)   

  • Online:2011-05-20 Published:2011-05-20

摘要: 用铁、铜和锌的盐酸盐,按比例与右旋糖酐进行络合反应,所得产物经乙醇多次精制,并进行了理化性质、游离金属元素、含量和稳定性等的测定。结果表明,将产物制成注射液,经尾静脉注射,在8d内小鼠的增重差异极显著(P〈0.01)。

Abstract: The complexation reactions of hydrochlorate of Fe,Cu,Zn and dextran were made at certain proportion.The products were depurated for many times with ethanol and the physicochemical properties,dissociated metal elements,content of metals stability and other characters were determined.The results showed that the products was made into the injection and mice had extremely significant weight gain after they were injected with the injection by tail intravenous injection eight days(P0.01).

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