Abstract: Apoptosis is a spontaneous cell-suicide process triggered in response to physiological and pathological stress stimuli.It is an initiative,tightly regulated and gene controlled process with the participation of a series of enzymes.Apoptosis plays a key role in health and survival of multicellular organisms and plays an important role in the normal development of individuals.Apoptosis is significant in tissue differentiation,organ development and individual homeostasis.The new cells are produced,and the aging and mutant cells were cleared by apoptosis at the same time to ensure normal development and metabolism of organs and tissues.The paper reviews the research progress in apoptosis.