Abstract: Using sandwich enzyme-linked immunosorbent assay with antibodies against fecal antigen of Echinococcus granulosus, infection of echinococcus was investigated in Shepherd dogs in six banners （counties） in Inner Mongolia border area between 2008 and 2010. The infection of echinococcus in sheep and cattle was investigated in abattoir. The infection of echinococcus in humans was investigated by visiting the local disease prevention and control centers. As revealed by three-year continual investigation, the positive rate of fecal antigen of Echinococcus granulosus was 13.16% in dogs, and the highest was 16.15%. The pastoral areas had the highest positive rate, and the areas more close to border had more serious infection. The average infection rate of echinococcus was 13.66% in sheep and cattle, and the highest was 17.90%. The average infection intensity was 1,36. The survey indicated that echinococcus has still existed in Inner Mongolia border area and threatens health of human and domestic animals seriously. Attention should be paid to prevention and control of echinococcus infection.