Abstract: Imitating washing technology of cashmere in Mongolia and China, the inactivating effect of FMD virus in cashmere was detected under different washing temperatures and treating times as well as different drying temperatures and treating times. Results indicated that the FMD virus NM-zg99 strain in the cashmere could not be inactivated by treating in the washing water at below 64 ℃ for 60 min. However, the virus could be inactivated by treating at 65 ℃ for 60 min, 66 ℃ for 45 min, 75 ℃ for 10 min and 80 ℃ for 5 min. There was a close relation between drying temperature and the treating time for the inactivation of the virus in cashmere. The virus could be inactivated by treating at 70 ℃ for 35 min and 75 ℃ for 25 min, 80~90 ℃ for 20 min, 95~105 ℃ for 15 min and 110 ℃ for 10 min. The result provides technical reference for making test standard for importing cashmere washing in China and also has directive significance for the cashmere washing corporations to improve the washing technology of sheep wool and cashmere.