Abstract: The epidemic situation of pig foot-and-mouth disease was hard to be controlled and eliminated after expansion. It was critical to diagnose timely and exactly and start up the predetermined plan of pig foot-and-mouth disease as early for preventing and controlling this disease. The etiology, serology, molecular biology and other diagnosis methods of pig foot-and -mouth disease were introduced in detail. A series of comprehensive prevention and control measures were proposed according to the principals of ＂early, fast, severe and small＂, so as to provide references for the effective control of pig foot and mouth disease.