Abstract: Piglet＇s yellow and white dysentery is a bacterial intestinal disease caused by E. col i and is characterized by defecating yellow or white dilute feces. The occurrence of this disease is observed in the four seasons. This disease always has high incidence and mortality in piglet＇s population and brings huge economic losses to the pig farmers. In order to find specific treatment protocol for the piglet＇s yellow-white dysentery, by interviewing and consulting the experienced traditional Chinese veterinarians, we summed up a specific prescription for the treatment of this disease. It was proved to be effective by clinical treatment of 280 cases. Our results may provide references for the pig farmers and veterinarians.