等位基因特异性表达形成机制及其应用的研究进展

doi:10.12160/j.issn.1672-5190.2019.06.011

Animal Husbandry and Feed Science ›› 2019, Vol. 40 ›› Issue (6): 37-40.doi: 10.12160/j.issn.1672-5190.2019.06.011

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Research Progress on Formation Mechanism of Allele Specific Expression and Its Application

DAI Hao-yang^1,2,BAI Xue^1,2,WANG Jian-meng^1,2,CHAI Yuan^1,2,FU Shao-yin^2,3,4,LIU Yong-bin³,ZHANG Wen-guang^1,2

1.College of Animal Science，Inner Mongolia Agricultural University，Hohhot 010018，China；
2.Key Laboratory of Animal Genetics，Breeding and Reproduction of Inner Mongolia，Hohhot 010018，China；
3.Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences，Hohhot 010031，China；
4.Inner Mongolia ATCG Institute of Bioinformatics，Hohhot 010020，China

Received:2019-03-21 Online:2019-06-30 Published:2019-12-25

Abstract

Abstract: Genes, as mediators of genetic information, determine the performance of the creature′s traits. The occurrence of genetic sequence variation is an inevitable trend of organisms to adapt to the environmental changes. The allele in the diploid organism is a pair of genes that controls relative traits. Therefore, the effect of allele specific expression varies depending on the cell type and its developmental stage, showing differences between different individuals. Differential expression of alleles plays an important role in the regulation of gene expression and may ultimately be linked to phenotypic polymorphisms in organisms. Allele specific expression analysis has been widely used in animal studies to help improve the ability to identify and regulate genetic variation. The research progress on the formation mechanism of allele specific expression and its application is reviewed, in hoping to provide a theoretical basis for further revealing the genetic mechanism of allele specific expression and accelerating its application in animal production.

Key words: phenotypic polymorphisms, allele specific expression, genetic variation

CLC Number:

S813

DAI Hao-yang,BAI Xue,WANG Jian-meng,CHAI Yuan,FU Shao-yin,LIU Yong-bin,ZHANG Wen-guang. Research Progress on Formation Mechanism of Allele Specific Expression and Its Application[J]. Animal Husbandry and Feed Science, 2019, 40(6): 37-40.

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Research Progress on Formation Mechanism of Allele Specific Expression and Its Application

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