Animal Husbandry and Feed Science ›› 2025, Vol. 46 ›› Issue (5): 50-57.doi: 10.12160/j.issn.1672-5190.2025.05.006

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Research Progress on the Regulatory Mechanisms of miRNAs Related to Animal Hair Follicle Development

ZHU Mengyao1,2, WANG Limin1, ZHOU Ping1, XU Mengsi1,3, GAN Shangquan4   

  1. 1. Institute of Animal Husbandry and Veterinary Medicine, Xinjiang Academy of Agricultural and Reclamation Science, Shihezi 832000, China;
    2. College of Animal Sciences, Xinjiang Agricultural University, Urumqi 830000, China;
    3. College of Animal Science and Technology, Shihezi University, Shihezi 832000, China;
    4. College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China
  • Received:2025-05-20 Published:2025-12-25

Abstract: The hair follicle is the basis for hair growth and an important component of the skin. Its development is regulated by the synergistic effects of multiple factors. The development of the hair follicle and its cyclical phases-anagen, catagen, and telogen-are precisely regulated by non-coding RNAs, particularly microRNAs (miRNAs). miRNAs influence the normal development and regeneration of hair follicles by interacting with various signaling pathways and target genes, thereby modulating the dynamic balance among cell proliferation, differentiation, and apoptosis. This review elaborates on the regulatory mechanisms of miRNAs in animal hair follicle development and discusses their role in regulating the proliferation, differentiation, and apoptosis of related cells, with the aim of providing a reference for improving fiber quality.

Key words: animal hair follicle development, miRNA, target genes, signaling pathways

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