[1] 杨苗苗,向海,李瑞瑞,等.gga-miR-17-5p在鸡骨骼肌和脂肪沉积相关组织及细胞中的表达差异及其关键靶基因的筛选[J].中国农业大学学报,2024,29(7):23-33. [2] 辛翔飞,郑麦青,文杰,等.2023年我国肉鸡产业形势分析、未来展望与对策建议[J].中国畜牧杂志,2024,60(3):312-317. [3] CHEN P, XU T T, ZHANG C D, et al.Effects of probiotics and gut microbiota on bone metabolism in chickens:a review[J].Metabolites,2022,12(10):1000. [4] SZAFRANIEC G M, SZELESZCZUK P, DOLKA B.Review on skeletal disorders caused by Staphylococcus spp. in poultry[J].The Veterinary Quarterly,2022,42(1):21-40. [5] 程义美,宰祥瑞.中草药特点及在兽医临床中的应用[J].畜牧兽医科学,2021(12):175-176. [6] 张霞,王志方,刘佳佳,等.中草药制剂在家禽中应用的研究进展[J].饲料工业,2023(17):36-41. [7] HE J B, LI X J, WANG Z Y, et al.Therapeutic anabolic and anticatabolic benefits of natural Chinese medicines for the treatment of osteoporosis[J].Frontiers in Pharmacology,2019,10:1344. [8] RIZZOLI R.Dairy products and bone health[J].Aging Clinical and Experimental Research,2022,34(1):9-24. [9] CHEN S, HE T L, ZHONG Y M, et al.Roles of focal adhesion proteins in skeleton and diseases[J].Acta Pharmaceutica Sinica B,2023,13(3):998-1013. [10] LIU K L, HE Y F, XU B W, et al.Leg disorders in broiler chickens:a review of current knowledge[J].Animal Biotechnology,2023,34(9):5124-5138. [11] 孔安安,陶坤盛,曹芹芹,等.巴戟天多糖对胫骨软骨发育不良的肉鸡生产性能、胫骨指数、胫骨钙磷灰分和血清电解质的影响[J].畜牧与饲料科学,2019,40(11):7-13. [12] LIU K P, FAN R B, ZHOU Z L.Endoplasmic reticulum stress, chondrocyte apoptosis and oxidative stress in cartilage of broilers affected by spontaneous femoral head necrosis[J].Poultry Science,2021,100(8):101258. [13] 陈飞鸿. 鸡钙磷缺乏症的临床症状与防治措施[J].养殖与饲料,2025,24(8):93-95. [14] GUO Y P, TANG H H, WANG X N, et al.Clinical assessment of growth performance, bone morphometry, bone quality, and serum indicators in broilers affected by Valgus-Varus deformity[J].Poultry Science,2019,98(10):4433-4440. [15] 王璐耀. 限饲程度对天府农华麻鸭胸骨钙化的影响研究[D].雅安:四川农业大学,2023. [16] TAKIGAWA M.CTGF/Hcs24 as a multifunctional growth factor for fibroblasts, chondrocytes and vascular endothelial cells[J].Drug News and Perspectives,2003,16(1):11-21. [17] DUFF S R I. Dyschondroplasia of the caput femoris in skeletally immature broilers[J].Research in Veterinary Science,1984,37(3):293-302. [18] KHOTIB J, MARHAENY H D, MIATMOKO A, et al.Differentiation of osteoblasts:the links between essential transcription factors[J].Journal of Biomolecular Structure and Dynamics,2023,41(19):10257-10276. [19] CHERIFI C, MONTEAGUDO S, LORIES R J. Promising targets for therapy of osteoarthritis:a review on the Wnt and TGF-β signalling pathways[J].Therapeutic Advances in Musculoskeletal Disease,2021,13:1759720X211006959. [20] YANG X M, MOU D G, YU Q Y, et al.Nerve growth factor promotes osteogenic differentiation of MC3T3-E1 cells via BMP-2/Smads pathway[J].Annals of Anatomy-Anatomischer Anzeiger,2022,239:151819. [21] 郭圣峰,孙立.骨生长因子在骨修复中的研究进展[J].标记免疫分析与临床,2020,27(1):173-177. [22] YANG D B, WAN Y H.Molecular determinants for the polarization of macrophage and osteoclast[J].Seminars in Immunopathology,2019,41(5):551-563. [23] 黄彬. 成骨细胞内mTORCl信号通路对骨形成和骨内血管形成的作用及其机制研究[D].广州:南方医科大学,2016. [24] 赵净颖,李丰耘,赵若含,等.中草药对鸡骨健康的调控作用[J].饲料研究,2024,47(8):170-175. [25] 周志锋,郭会卿,曹玉举,等.中医药通过OPG/RANKL/RANK系统干预类风湿关节炎骨破坏的研究进展[J].中医学报,2023,38(1):77-82. [26] KOVÁCS B, VAJDA E, NAGY E E. Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis[J].International Journal of Molecular Sciences,2019,20(18):4653. [27] 邱世明,董万涛,刘静怡,等.中药干预RANKL信号通路调控破骨细胞治疗骨质疏松症的作用机制[J].中国骨质疏松杂志,2024,30(10):1455-1460. [28] 吴亚洲,陈威,赵海燕,等.骨骼疾病巨噬细胞与破骨细胞交互作用的研究进展[J].中国矫形外科杂志,2023,31(19):1778-1782. [29] VAROL C, MILDNER A, JUNG S.Macrophages:development and tissue specialization[J].Annual Review of Immunology,2015,33:643-675. [30] DONG C.Cytokine regulation and function in T cells[J]. Annual Review of Immunology,2021,39:51-76. [31] KITAURA H, MARAHLEH A, OHORI F, et al.Osteocyte-related cytokines regulate osteoclast formation and bone resorption[J].International Journal of Molecular Sciences,2020,21(14):5169. [32] 周振雷,张旻,刘德义.肉鸡股骨头坏死研究进展[J].安徽科技学院学报,2019,33(5):1-5. [33] GROVES P J, MUIR W I.Earlier hatching time predisposes Cobb broiler chickens to tibial dyschondroplasia[J].Animal,2017,11(1):112-120. [34] 彭荟桢,蔡明详,刘湘宁.骨修复过程中的血管生成调控:新思路与新方法[J].中国组织工程研究,2022,26(15):2400-2405. [35] 关晓瑞,任新华,乔宁宁,等.外源性神经生长因子对肱骨骨折大鼠破骨细胞活性、血管形成及iRhom2/TACE信号通路的作用[J].解剖学杂志,2023,46(4):297-303. [36] 黄淑成. 缺氧和福美双对藏鸡和肉鸡胫骨血管化的作用机制及其对胫骨生长的影响[D].武汉:华中农业大学,2018. [37] 申震,姜自伟,陈国茜,等.成血管-成骨耦联相关因子、细胞在骨中作用机制的研究进展[J].中国骨质疏松杂志,2020,26(3):458-463. [38] MABETA P, STEENKAMP V.The VEGF/VEGFR axis revisited:implications for cancer therapy[J].International Journal of Molecular Sciences,2022,23(24):15585. [39] LIU X D, CAI F, LIU L, et al.microRNA-210 is involved in the regulation of postmenopausal osteoporosis through promotion of VEGF expression and osteoblast differentiation[J].Biological Chemistry,2015,396(4):339-347. [40] 尹子丽,谭文红,冯德强,等.骨碎补的本草考证及炮制、药用历史沿革[J].中国药房,2019,30(12):1725-1728. [41] 马克昌,朱太咏,刘鲜茹,等.骨碎补注射液对培养中鸡胚骨原基钙化的促进作用[J].中国中药杂志,1995,(3):178-180,193. [42] 郑晶晶. 骨碎补总黄酮改善肉鸡胫骨软骨发育不良的试验研究[D].郑州:河南农业大学,2022. [43] YAO W Y, ZHANG H, JIANG X, et al.Effect of total flavonoids of rhizoma drynariae on tibial dyschondroplasia by regulating BMP-2 and Runx2 expression in chickens[J].Frontiers in Pharmacology,2018,9:1251. [44] HUANG J, TONG X F, YU Z W, et al.Dietary supplementation of total flavonoids from Rhizoma Drynariae improves bone health in older caged laying hens[J].Poultry Science,2020,99(10):5047-5054. [45] 郑素玉,陈健.巴戟天有效成分及其药理作用实验研究进展[J].世界中西医结合杂志,2012,7(9):823-825,828. [46] ZHANG C D, XU T T, LIN L X, et al.Morinda officinalis polysaccharides ameliorates bone growth by attenuating oxidative stress and regulating the gut microbiota in thiram-induced tibial dyschondroplasia chickens[J].Metabolites,2022,12(10):958. [47] 曹芹芹,岳珂,林露茜,等.福美双对肉鸡股骨生长发育的影响及巴戟天多糖保护效果的研究[J].畜牧与饲料科学,2021,42(4):110-117. [48] HUANG S C, CAO Q Q, CAO Y B, et al.Morinda officinalis polysaccharides improve meat quality by reducing oxidative damage in chickens suffering from tibial dyschondroplasia[J].Food Chemistry,2021,344:128688. [49] ZHENG X D, YU Y, SHAO B Y, et al.Osthole improves therapy for osteoporosis through increasing autophagy of mesenchymal stem cells[J].Experimental Animals,2019,68(4):453-463. [50] WAQAS M, WANG Y P, LI A Y, et al.Osthole:a coumarin derivative assuage thiram-induced tibial dyschondroplasia by regulating BMP-2 and RUNX-2 expressions in chickens[J].Antioxidants,2019,8(9):330. [51] 沐韦,沈晓峰,张国栋,等.蛇床子素通过抑制NF-κB诱导间充质干细胞成骨分化的实验研究[J].中华中医药学刊,2023,41(12):159-164. [52] 胡妮娜,张晓娟.黄芪的化学成分及药理作用研究进展[J].中医药信息,2021,38(1):76-82. [53] MEHMOOD K, ZHANG H, YAO W Y, et al.Protective effect of Astragaloside Ⅳ to inhibit thiram-induced tibial dyschondroplasia[J].Environmental Science and Pollution Research International,2019,26(16):16210-16219. [54] 高子范,马克昌,杨宗智,等.黄芪注射液对培养中鸡胚软骨生长的促进作用[J].中草药,1988,19(5):18-20,28. [55] 刘宝. 日粮添加黄芪多糖对蛋鸡生产性能和蛋品质的影响[J].中国畜禽种业,2023,19(10):120-123. [56] 张加豪,李嘉程,温明韬,等.黄芪甲苷可缓解MC3T3-E1细胞氧化应激损伤并促进成骨[J].中国组织工程研究,2025,29(17):3529-3536. [57] 史晨旭,杜佳蓉,吴威,等.葛根化学成分及药理作用研究进展[J].中国现代中药,2021,23(12):2177-2195. [58] WAQAS M, QAMAR H, ZHANG J L, et al.Puerarin enhance vascular proliferation and halt apoptosis in thiram-induced avian tibial dyschondroplasia by regulating HIF-1α, TIMP-3 and BCL-2 expressions[J].Ecotoxicology and Environmental Safety,2020,190:110126. [59] 曾锁林,施能兵,刘异.葛根素对激素性股骨头坏死大鼠骨组织及PI3K/Akt信号转导通路的影响[J].蚌埠医学院学报,2019,44(11):1441-1444. [60] 赵文静,王历,王芝兰,等.淫羊藿的药理作用及临床应用研究进展[J].中医药信息,2016,33(2):105-108. [61] 张辉. 福美双致肉鸡胫骨软骨发育不良的分子机制及淫羊藿苷的治疗作用[D].武汉:华中农业大学,2019. [62] IQBAL M, ZHANG H, MEHMOOD K, et al.Icariin:a potential compound for the recovery of tibial dyschondroplasia affected chicken via up-regulating BMP-2 expression[J].Biological Procedures Online,2018,20(1):15. [63] HUANG J, HU Y P, TONG X F, et al.Untargeted metabolomics revealed therapeutic mechanisms of icariin on low bone mineral density in older caged laying hens[J].Food and Function,2020,11(4):3201-3212. [64] 石威,金鑫,王金凤,等.淫羊藿苷介导PI3K/Akt信号通路干预大鼠早期激素性股骨头坏死的研究[J].现代药物与临床,2022,37(12):2680-2686. [65] 王昊翔,江树连,袁杰,等.基于网络药理学和分子对接技术研究当归-川芎治疗骨折的作用机制[J].中医临床研究,2025,17(1):15-22. [66] ZHANG H, WANG Y J, MEHMOOD K, et al.Treatment of tibial dyschondroplasia with traditional Chinese medicines:"Lesson and future directions"[J].Poultry Science,2020,99(12):6422-6433. [67] ZHANG L, DENG M Y, ZHOU S W.Tetramethylpyrazine inhibits hypoxia-induced pulmonary vascular leakage in rats via the ROS-HIF-VEGF pathway[J].Pharmacology,2011,87(5/6):265-273. [68] MEHMOOD K, ZHANG H, LI K, et al.Effect of tetramethylpyrazine on tibial dyschondroplasia incidence, tibial angiogenesis, performance and characteristics via HIF-1α/VEGF signaling pathway in chickens[J].Scientific Reports,2018,8(1):2495. [69] 万新焕,王瑜亮,周长征,等.丹参化学成分及其药理作用研究进展[J].中草药,2020,51(3):788-798. [70] 樊长苗. 丹参提取物对鸡胚绒毛尿囊膜血管新生的实验研究[D].北京:北京中医药大学,2008. [71] MEHMOOD K, ZHANG H, IQBAL M K, et al.In vitro effect of apigenin and Danshen in tibial dyschondroplasia through inhibition of heat-shock protein 90 and vascular endothelial growth factor expressions in avian growth plate cells[J].Avian Diseases,2017,61(3):372-377. [72] 齐伟,刘建军,王凯,等.当归活性成分治疗骨关节炎的药理学机制研究进展[J].中国医院药学杂志,2024,44(14):1708-1714. [73] 靳录洋,徐小芳,谷新利.当归多糖对鸡抗氧化功能的影响[J].中国兽医杂志,2017,53(6):76-79. [74] 牛永莉,柳树英,丁海霞.当归多糖促进鸡胚绒毛尿囊膜血管生成的实验研究[J].甘肃中医,2009,22(9):71-72. [75] 徐翀,申利民,苑文杰.当归多糖通过Wnt/β-catenin信号通路抑制骨关节炎软骨细胞氧化应激损伤与炎症反应[J].陕西中医,2022,43(6):700-703,770. [76] LIU Y, LIANG S M, ZI X N, et al.Influence of Chinese herbal formula on bone characteristics of Cobb broiler chickens[J].Genes,2022,13(10):1865. [77] 董清平,刘昱,董华.中药制剂(骨痛仙)对鸡股骨头缺血性坏死自由基清除作用的实验研究[J].中医药信息,1999(6):42-43. [78] XU T T, CHEN P,ZHANG C D, et al.Gut microbiome dysregulation drives bone damage in broiler tibial dyschondroplasia by disrupting glucose homeostasis[J].NPJ Biofilms and Microbiomes,2023,9(1):1. [79] MALEMATJA E, MANYELO T G, NG′AMBI J W, et al. Effects of onion extracts (Allium cepa) inclusion in diets on growth performance, carcass characteristics, and bone morphometric of broiler chickens[J].Animal Bioscience,2023,36(7):1075-1082. [80] ZHANG J L, HUANG S C, TONG X L, et al.Chlorogenic acid alleviates thiram-induced tibial dyschondroplasia by modulating caspases, BECN1 expression and ECM degradation[J].International Journal of Molecular Sciences,2019,20(13):3160. |