Abstract: The aim of the study was to provide an experimental basis for investigating the effects of noise on nervous system,especially learning and memory.The changes in learning and memory of mice were observed in simulated noise environment.The mice were interfered with noise at a sound intensity of about 80 decibels every day for 1 month.Morris water maze system was used for determination of learning and memory.During the 5-day learning training,the incubation time for the experimental mice to find platform on Day 3 was（30.96 ± 0.041） s,which was significantly longer than that of control group（15.73 ± 0.041） s（P〈 0.05）.However,in the memory test which was performed after 1 week,the incubation time for the experimental mice to find platform on Day 3 was（10.30± 0.045） s,which was significantly shorter than that of control group（29.13 ± 0.045） s（P 〈0.05）.This result demonstrated good memories of the experimental mice.Therefore,noise of 80 decibels affects learning and temporary memory of mice,and long-term memory in mice can be well maintained by noise interference.