Abstract: Bisphenol A （BPA） is a widespread estrogenic chemical. In rodents, BPA are passed quickly from mother to fetus. In perinatal period, brain and the nervous system are very sensitive to alteration of environment. To investigate the effects of perinatal exposure to BPA on exploration, male mice were garaged with BPA at a dosage of 2 （Group Ⅰ ） and 200μg/（kg·bw） （Group Ⅱ ）, respectively. At 70 days old, the behaviors of male offspring were observed in a new cage. The results indicated that their exploration was enhanced. The male offspring borne by the male mice in the group II had stronger exploration significantly. The male offspring borne by the male mice in the group I also had higher exploration frequency than the control group, but the difference was not significant. Therefore, perinatal exposure to BPA in perinatal period can enhance the exploration of male offspring, and this effect may be in a dose- dependent manner.