Abstract: Adopt the design of combination of quadratic regression rotation,and choose the main cultivation factors just like the planting density, nitrogen, phosphor, Potash as the decision variable,and then choose the output as the the objective function. Found the mathematical model between the output of pigment marigold and cultivation factors,men by the means of Simulation optimization,we have descided the combined program of Cultivation measures which can made the average yield reach oevr 2388kg/667m^2. It is planting density 2654 -2769 株/667m^2, Nitrogen （N） 3.65-3.99kg/667m^2, Phosphate （P2O5）5.5-5.96kg/667m^2, Potash （K2O）3.52-3.67kg/667m^2.