Abstract: Fish Physiology is one of the most important professional basic course for aquaculture profession, hence the reform of teaching methods for the course is especially important to obtain good teaching effect. In this paper, according to teaching features and problems of Fish Physiology, the teaching reform of Fish Physiology were discussed from the aspects of choice of reference books, teaching methods and models, so as to provide good strategies for the teaching reform, stimulate students′ interest in learning, and finally achieve good teaching effect.