群体感应系统调控细菌生物膜的研究进展

doi:10.12160/j.issn.1672-5190.2020.05.002

摘要/Abstract

摘要： 主要介绍了细菌生物膜的概念及其形成过程、细菌群体感应（QS）的概念以及革兰阴性菌的AHL-LuxI/LuxR型QS系统、革兰阳性菌的QS系统、LuxS/AI-2介导的种间QS系统、AI-3/肾上腺素/去甲肾上腺素信息系统4种QS系统的调节机制。就QS系统在细菌中发挥的作用以及对生物膜的调控进行初步阐述，以期为乳酸菌的开发利用和致病菌耐药性的研究提供参考。

关键词: 细菌生物膜, 群体感应, 乳酸菌, 致病菌

Abstract: This paper introduces the bacterial biofilm and its formation process, describes the conception of bacterial quorum sensing （QS） system, and expounds four types of regulative mechanism of QS system, including the AHL-LuxI/LuxR based QS system in Gram-negative bacteria, the QS system in Gram-positive bacteria, the LuxS/AI-2 mediated interspecific QS system, and the AI-3/ epinephrine/norepinephrine signaling system. The roles of QS system in bacteria and its regulative mechanism in formation of bacterial biofilm are elaborated, in hoping to provide references for the development of lactic acid bacteria agents and the investigations on antimicrobial resistance of pathogenic bacteria.

Key words: bacterial biofilm, quorum sensing, lactic acid bacteria, pathogenic bacteria

中图分类号:

Q935

钟华晨, 贺银凤. 群体感应系统调控细菌生物膜的研究进展[J]. 畜牧与饲料科学, 2020, 41(5): 7-12.

ZHONG Hua-chen, HE Yin-feng. Research Advances on Regulative Role of Quorum Sensing System in Formation of Bacterial Biofilm[J]. Animal Husbandry and Feed Science, 2020, 41(5): 7-12.

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