畜禽生产中氧化应激分子调控机理及营养策略研究进展

doi:10.12160/j.issn.1672-5190.2021.04.006

畜牧与饲料科学 ›› 2021, Vol. 42 ›› Issue (4): 29-36.doi: 10.12160/j.issn.1672-5190.2021.04.006

畜禽生产中氧化应激分子调控机理及营养策略研究进展

张心壮^1,2,3,4, 曹迪^1,2,3,4, 格日乐其木格^1,2,3,4, 芒来^1,2,3,4

1.内蒙古农业大学动物科学学院,内蒙古呼和浩特 010018;
2.内蒙古自治区马属动物遗传育种与繁殖重点实验室,内蒙古呼和浩特 010018;
3.农业农村部马属动物遗传育种与繁殖科学观测实验站,内蒙古呼和浩特 010018;
4.内蒙古农业大学马属动物研究中心,内蒙古呼和浩特 010018

收稿日期:2021-02-24 出版日期:2021-07-30 发布日期:2021-08-25
通讯作者: 芒来（1962—）,男,教授,博士,博士生导师,主要从事马属动物遗传育种研究工作。
作者简介:张心壮（1989—）,男,讲师,博士,主要从事马属动物营养与产品品质研究工作。
基金资助:
国家自然科学基金项目（31902188）; 内蒙古农业大学高层次引进人才启动项目（NDGCC2016-01）; 内蒙古农业大学动物科学学院青年基金项目（QN202030）; 国家重点研发计划项目（2017YFE0108700）

Research Advances on Molecular Regulatory Mechanisms of Oxidative Stress and Nutritional Strategies in Livestock and Poultry Production

ZHANG Xin-zhuang^1,2,3,4, CAO Di^1,2,3,4, Gerelchimeg^1,2,3,4, Manglai^1,2,3,4

1. College of Animal Science,Inner Mongolia Agricultural University,Hohhot 010018,China;
2. Inner Mongolia Key Laboratory of Equine Genetics,Breeding and Reproduction,Hohhot 010018,China;
3. Scientific Observing and Experimental Station of Equine Genetics,Breeding and Reproduction,Ministry of Agriculture and Rural Affairs,Hohhot 010018,China;
4. Equine Research Center,Inner Mongolia Agricultural University,Hohhot 010018,China

Received:2021-02-24 Online:2021-07-30 Published:2021-08-25

摘要/Abstract

摘要： 现代畜禽生产过程中发生的氧化应激损害畜禽健康,降低畜禽生产性能。现代系统动物营养学认为畜禽体内自由基稳态失衡是导致氧化应激—炎症反应—免疫功能失衡,威胁畜禽健康,降低畜禽生产性能的根本原因。畜禽体内多种信号通路组成的调控网络共同维持自由基稳态。综述了p38MAPK、Nrf2-ARE、NF-κB等氧化应激相关信号通路在畜禽生产中的调控机制及其营养策略研究进展,以期为畜禽生产中缓解氧化应激损伤,保障动物福利,提高生产性能提供参考。

关键词: 畜禽生产, 氧化应激, 信号通路, 营养策略

Abstract: Oxidative stress that occurs in modern livestock and poultry production brings damages to the health and reduces the performance of livestock and poultry. Modern systematic animal nutrition believes that the imbalance of free radical homeostasis in livestock and poultry is the root cause leading to the oxidative stress-inflammatory response-immune function imbalance, which threatens the health and reduces the performance of livestock and poultry. A regulatory network composed of multiple signaling pathways in livestock and poultry maintains the free radical homeostasis together. In this paper, research advances on regulatory mechanisms of p38MAPK, Nrf2-ARE, NF-κB and other oxidative stress related signaling pathways in livestock and poultry production and corresponding nutritional strategies are reviewed, in hoping to provide references for alleviating oxidative stress damages, ensuring animal welfare, and improving production performance in livestock and poultry production.

Key words: livestock and poultry production, oxidative stress, signaling pathway, nutritional strategy

中图分类号:

Q257
S815

张心壮, 曹迪, 格日乐其木格, 芒来. 畜禽生产中氧化应激分子调控机理及营养策略研究进展[J]. 畜牧与饲料科学, 2021, 42(4): 29-36.

ZHANG Xin-zhuang, CAO Di, Gerelchimeg, Manglai. Research Advances on Molecular Regulatory Mechanisms of Oxidative Stress and Nutritional Strategies in Livestock and Poultry Production[J]. Animal Husbandry and Feed Science, 2021, 42(4): 29-36.

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畜禽生产中氧化应激分子调控机理及营养策略研究进展

Research Advances on Molecular Regulatory Mechanisms of Oxidative Stress and Nutritional Strategies in Livestock and Poultry Production

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