动物毛囊发育相关miRNA的调控机制研究进展

doi:10.12160/j.issn.1672-5190.2025.05.006

摘要/Abstract

摘要： 毛囊是毛发生长的基础,同时也是皮肤的重要组成部分,其发育过程受多种调控因子协同作用。毛囊的发育及其生长期、退行期、休止期的周期循环受到非编码RNA,尤其是微小核糖核酸（miRNA）的精密调控。miRNA能够通过与不同信号通路及靶基因相互作用,调节细胞增殖、分化与凋亡之间的动态平衡,从而对毛囊的正常发育与再生产生影响。阐述miRNA在动物毛囊发育方面的调控机制,并探讨其对相关细胞增殖、分化和凋亡的调节作用,以期为改善绒毛品质提供参考。

关键词: 动物毛囊发育, miRNA, 靶基因, 信号通路

Abstract: The hair follicle is the basis for hair growth and an important component of the skin. Its development is regulated by the synergistic effects of multiple factors. The development of the hair follicle and its cyclical phases-anagen, catagen, and telogen-are precisely regulated by non-coding RNAs, particularly microRNAs （miRNAs）. miRNAs influence the normal development and regeneration of hair follicles by interacting with various signaling pathways and target genes, thereby modulating the dynamic balance among cell proliferation, differentiation, and apoptosis. This review elaborates on the regulatory mechanisms of miRNAs in animal hair follicle development and discusses their role in regulating the proliferation, differentiation, and apoptosis of related cells, with the aim of providing a reference for improving fiber quality.

Key words: animal hair follicle development, miRNA, target genes, signaling pathways

中图分类号:

S813
S852.2

朱梦瑶, 王立民, 周平, 徐梦思, 甘尚权. 动物毛囊发育相关miRNA的调控机制研究进展[J]. 畜牧与饲料科学, 2025, 46(5): 50-57.

ZHU Mengyao, WANG Limin, ZHOU Ping, XU Mengsi, GAN Shangquan. Research Progress on the Regulatory Mechanisms of miRNAs Related to Animal Hair Follicle Development[J]. Animal Husbandry and Feed Science, 2025, 46(5): 50-57.

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