畜牧与饲料科学 ›› 2020, Vol. 41 ›› Issue (4): 85-89.doi: 10.12160/j.issn.1672-5190.2020.04.017

• 兽医药物科学 • 上一篇    下一篇

柴桂感寒口服液对鸡外感风寒治疗作用的初步研究

禹方晓1, 刘明研2, 肖蕊1, 施君1, 曾芸1, 韦英益1, 胡庭俊1   

  1. 1.广西大学动物科学技术学院,广西 南宁 530005;
    2.广西百色农业学校,广西 百色 533099
  • 收稿日期:2019-12-06 出版日期:2020-07-30 发布日期:2020-08-19
  • 通讯作者: 胡庭俊(1965—),男,研究员,博士,博士生导师,主要研究方向为兽医药理学和毒理学。韦英益(1973—),女,副教授,博士,硕士生导师,主要研究方向为动物疾病病理学。胡庭俊、韦英益为共同通信作者。
  • 作者简介:禹方晓(1993—),男,硕士研究生,主要研究方向为中兽药药理学。刘明研(1986—),男,高级讲师,硕士研究生,主要研究方向为兽医药理学。禹方晓、刘明研为共同第一作者。
  • 基金资助:
    广西大学校企合作项目(20170118); 南宁市科学研究与技术开发计划项目(20175031-4)

Therapeutic Effect of Chaigui Cold Oral Liquid on Exogenous Wind-chill in Chickens

YU Fang-xiao1, LIU Ming-yan2, XIAO Rui1, SHI Jun1, ZENG Yun1, WEI Ying-yi1, HU Ting-jun1   

  1. 1. College of Animal Science and Technology,Guangxi University,Nanning 530005,China;
    2. Baise Agricultural School of Guangxi,Baise 533099,China
  • Received:2019-12-06 Online:2020-07-30 Published:2020-08-19

摘要: 旨在确定柴桂感寒口服液临床给药剂量及其与疗效的关系,评价该药物的临床治疗效果,并筛选临床推荐剂量。建立鸡外感风寒模型,设6个柴桂感寒口服液药物治疗剂量组、1个模型对照组、1个健康对照组,每组30只鸡;连续给药5 d,停药后持续观察7 d,通过有效率、治愈率和增重率指标综合评定临床疗效,确定最佳的临床给药剂量。结果表明,连续用药5 d后,按1.0 mL/L添加柴桂感寒口服液试验组的总有效率为93.33%,治愈率为76.67%,增重率为223.40%;按8.0 mL/L添加柴桂感寒口服液试验组的总有效率为100%,治愈率为86.67%,增重率为319.75%。结果表明,综合柴桂感寒口服液临床治疗的有效率、治愈率,以及用药后的临床表现、平均增重和药物成本等因素,确定柴桂感寒口服液对鸡外感风寒的临床用药剂量、给药方式、疗程为每升水中添加1.0 mL、混饮、连用3~5 d。

关键词: 柴桂感寒口服液, 鸡, 有效率, 治愈率

Abstract: This study aimed to investigate the relationship between administrative dosage and therapeutic effect, evaluate the clinical therapeutic efficacy, and select the recommended dosage of Chaigui cold oral liquid. The exogenous wind-chill model was established with chickens. A total of 6 groups received different dosages of Chaigui cold oral liquid, a model control group, and a healthy control group were included in this study. There were 30 chickens in each group. After a continuous administration for 5 days, the chickens were observed persistently for 7 days. To determine the optimal administrative dosage, the clinical efficacy of different dosages of Chaigui cold oral liquid was comprehensively evaluated via the indicators of effective rate, curative rate and weight gain rate. The results showed that after 5 days treatment, the total effective rate, curative rate and weight gain rate of the chickens received the administration of 1.0 mL/L of Chaigui cold oral liquid were 93.33%, 76.67% and 223.40%, respectively, and those of the chickens received the administration of 8.0 mL/L of the liquid were 100%, 86.67% and 319.75%, respectively. Taking the factors of effective rate, curative rate, clinical manifestations, average weight gain and treatment cost into consideration, the clinical medication method of Chaigui cold oral liquid for exogenous wind-chill in chickens is as follows: adding 1.0 mL of the liquid in every 1 L of drinking water for continuous 3 to 5 days.

Key words: Chaigui cold oral liquid, chickens, effective rate, curative rate

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