Abstract: Diarrhea,one of the serious illnesses affecting the growth and development of domestic animals in the scale animal and poultry cultivation,hinders the development of the raising industry.Diarrhea has been become the main causes to death and growth retardation of animal,specially to young livestock,such as piglets and chicken.Nowadays,the addition of antibiotics,hormones and the synthesized chemical drugs often used to prevent or treat it,thus it lead to drug resistance and drug residue.Therefore,fermentation products added in the feeds include probiotics,vitamins,amino acids,enzymes and so on get rapid development.In the article,the application of microbial feed additive and its production technique was reviewed.