Abstract: [Objective] To select the best ultrasonic extraction process for separating effective ingredients from Zengye Chengqi decoction. [Method] Ultrasonic power, extraction temperature and extraction time at three levels were compared by orthogonal design test, and the optimum process was selected based on recovery rate of main effective ingredients. [Result] The best conditions are as follows： ultrasonic power, 360 W; extraction temperature, 60 °C; and extraction time, 20 min. [Conclusion] The method is reasonable and feasible to extract effective ingredients from Zengye Chengqi decoction.