Abstract: Taking BCA as monomer material,ivermectin polybutylcyanoacrylate nanoparticles（IVM-PBCA-NP） were prepared by emulsion polymerization method.The drug-loaded PVP-IVM-PBCA-NP was formed after drug adsorption and PVP coating.The optimum preparation conditions were confirmed by the orthogonal test as follows：the dosage ratio of BCA to IVM was 4：1（g/g）,the dosage of BCA was 0.4：25（V/V）,the concentration of emulsifier F68 was 2%,stirring speed was 600 r/min,reaction system pH was 2,3 and 6,reaction time was 3 h.Under these conditions,the drug encapsulation ratio of the prepared PVP-IVM-PBCA-NP was（45.43±1.65）%,the drug-loading capacity was（9.95±0.23）% and the main particle size was 296 nm.