Abstract: [Objective] The control effect of piglet early weaning diarrhea （PEWD） by adding glucose oxidase and phytohemagglutinin to diet was studied to explore the effect on performance and intestinal health of piglet. [Method] One hundred and twenty weaned piglets were randomly divided into three groups, that was controlled, group I and group 11. Under the uniform raising management pattern, piglets in control were fed on routine basal diet; piglets in group I were fed on diet with 0.5% glucose oxidase; piglets in group II were fed on diet with 0.5% glucose oxidase and 0.1% phytohemagglutinin. The diarrhea frequency, feed intake, death number and empty body weight per piglet in the beginning and at the end of the experiment were recorded every day. The average daily gain, diarrhea rate, average daily feed intake, feed conversion rate and mortality were calculated. [Result] Compared with control, the average daily gain of piglets in group I and II were significantly improved by 25.0% and 26.8% respectively（P〈0.01 ）; the feed conversion ratio of piglets in group I and I1 were significantly decreased by 17.2% and 18.7% respectively（P〈0.01 ）; the diarrhea rate of piglets in group I and II were significantly decreased by 56.0% and 65.5% respectively （P〈0.01）; the survival rates of piglets in group I and lI were improved by 7.4% （P〉0.05）and 13% （P〈0.01）, respectively. [Conclusion] Adding glucose oxidase and phytohemagglutinin to diet could improve feed conversion rate and piglet survival rate and obviously reduce piglet diarrhea rate.