Abstract: In recent years,the epidemic intensity of foot and mouth disease in China has been obviously weakened. But the prevention and control of foot and mouth disease couldn＇t be slacked because the prevalence of foot and mouth disease showed the periodicity. The epidemic situations of foot and mouth disease in China, the prevention and control of foot and mouth disease for common susceptible animals, research progress on the vaccine of foot and mouth disease and the related problems were mainly introduced, so as to provide references for preventing the outbreak of foot and mouth disease.