Animal Husbandry and Feed Science ›› 2017, Vol. 38 ›› Issue (10): 33-33.doi: 10.12160/j.issn.1672-5190.2017.10.010

Previous Articles     Next Articles

Research Progress on Action Mechanism and Application of Diphtheria Toxin

ZHANG Jing-feng1 , ZHU Kuan-you1 , XU Qiu-liang1 , ZHANG Chang-xing1 , LIU Jian1 , ZHANG Shou-quan2 (1.College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China; 2.Guangdong Provincial Key Laboratory of Agro-animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University Guangzhou 510642,China)   

  • Online:2017-10-20 Published:2017-10-20

Abstract: Diphtheria toxin is an exotoxin secreted by the ; phage infected Corynebacterium diphtheria strains. It is highly toxic and even one molecule can kill cells. Recently, it has been widely used in tumor therapy and preparation of animal disease models. We mainly review the structure and action mechanism of diphtheria toxin as well as its application in tumor therapy and animal models preparation, in hoping to provide a theoretical basis for further studies on diphtheria toxin.

CLC Number: