Abstract: [Objective] To assess the effects of dietary supplementation of compound traditional Chinese medicine （CTCM） on serum level of cholesterol and lipoprotein of piglets in nursery stage, and to provide references for the development of traditional Chinese medicine that can enhance the immunological functions of nursery piglets, for the reduction of antibiotics uses in livestock breeding industry, and for the antibiotics-free pork production. [Method] A total of 80 （28±2） -day-old ′Duroc×Landrace×Yorkshire′ three-way crossbred piglets with similar weight were randomly divided into 4 treatments （groups） with 2 replicates in each treatment （group） and 10 piglets in each replicate. The first group was served as a control group which fed a basal diet. The second, third and fourth groups were fed with the basal diet supplemented with 1.5%, 1.0% and 0.5% CTCM, respectively. The experimental period lasted for 4 weeks. On the second day after the end of the experiment, the blood samples were collected from anterior vena cava at 9:00 am before feeding, and the routine indicators of the whole blood were measured. [Result] Compared to the control group, the serum content of lipoprotein lipase in the nursery piglets with dietary supplementation of CTCM were all increased, and significant （P<0.05） difference was observed between the 0.5% CTCM addition group and control group. While the elevated serum level of high-density lipoprotein was observed in all of the CTCM addition groups compared to control group, no significant difference was observed（P>0.05）; the serum level of high-density lipoprotein of the nursery piglets was reduced with the decreasement of addition ration of the CTCM. Compared with the control group, the serum content of low-density lipoprotein of the CTCM addition groups were all reduced, and it was decreased with the reduction of addition ration of the CTCM; extremely significant （P<0.01） difference was found between the 0.5% CTCM addition group and control group. The serum content of triacylglycerol had the same changing feature with low-density lipoprotein, but no significant difference was observed between the CTCM addition groups and control group （P>0.05）. [Conclusion] Dietary supplementation of CTCM elevated the serum content of lipoprotein lipase and high-density lipoprotein of the crossbred nursery piglets, and reduced the serum level of low-density lipoprotein and triacylglycerol.

Key words: compound traditional Chinese medicine, nursery piglets, cholesterol, lipoprotein