微生态制剂在犊牛生长发育中的应用研究进展

doi:10.12160/j.issn.1672-5190.2026.02.005

Abstract

Abstract: With the development of global animal husbandry, the restrictions on the use of feed antibiotics have gradually increased. Microecological preparations can replace antibiotics in livestock and poultry production due to their green, safe, highly efficient, non-toxic, and low drug-resistance-inducing characteristics. Microecological preparations can promote the development of the animal immune system and intestinal tract, improve the body's immune performance, and enhance the mucosal physical barrier. They also possess multiple functions of regulating the composition and activity of intestinal microbiota, maintaining intestinal microbiota balance, improving digestive function, enhancing feed digestibility and utilization efficiency, promoting growth and development, and alleviating stress. The period from birth to weaning is a crucial period in the life cycle of calves. The health status of calves at this stage is directly related to their adult productivity, overall health and breeding efficiency. Based on this, with summarizing the different types and functions of microecological preparations, this paper reviews the regulatory mechanisms of microecological preparations in the growth and development of calves from the aspects of enhancing growth performance, improving body immunity and regulating intestinal microbiota balance and health, aiming to promote microecological preparations to play a greater role in advancing the development of calf breeding industry and accelerating the green transformation of animal husbandry.

Key words: calf, microecological preparations, growth and development, mechanism of action

CLC Number:

S816.7

XIN Liang, WANG Dezhi, YIN Wen, LI Cheng, LI Cuiting, XUAN Zhiwen, MA Yanfen. Research Progress on the Application of Microecological Preparations in Calf Growth and Development[J]. Animal Husbandry and Feed Science, 2026, 47(2): 36-41.

References

[1] 张乾赐. 液态复合微生态制剂对荷斯坦犊牛生长性能和健康状况的影响[D].南京:南京农业大学,2023.
[2] 钱娜. 不同复合微生态制剂对哺乳期犊牛的生长性能、血液指标及粪便微生物的影响[D].呼和浩特:内蒙古农业大学,2023.
[3] LOOSLI J K, WALLACE H D.Influence of APF and aureomycin on the growth of dairy calves[J].Experimental Biology and Medicine,1950,75(2):531-533.
[4] RUSOFF L L, DAVIS A V, ALFORD J A.Growth-promoting effect of aureomycin on young calves weaned from milk at an early age 1[J].The Journal of Nutrition,1951,45(2):289-300.
[5] QIAO M, YING G G, SINGER A C, et al.Review of antibiotic resistance in China and its environment[J].Environment International,2018,110:160-172.
[6] 郁冯艳,付佳伟,从光雷,等.微生态制剂在反刍动物生产中的研究与应用[J].广东饲料,2024,33(3):34-37.
[7] 宋雪莹. 微生态制剂在畜禽生产中的应用[J].山东畜牧兽医,2025,46(6):38-40.
[8] WANG Q, ZHANG Y T, CHENG X L, et al.Expert consensus on the use of oropharyngeal probiotic Bactoblis in respiratory tract infection and otitis media:available clinical evidence and recommendations for future research[J].Frontiers in Pediatrics,2025,12:1509902.
[9] HE M X, LIU L, LI Y, et al.Formation of gut microbiota and application of microecological regulators in children[J].Translational Pediatrics,2025,14(8):2023-2041.
[10] LI W T, KAI L X, JIANG Z P, et al.Bifidobacterium longum, Lactobacillus plantarum and Pediococcus acidilactici Reversed ETEC-Inducing Intestinal Inflammation in Mice[J].Microorganisms,2022,10(12):2350.
[11] SUN M Y, LIU Y J, SONG Y L, et al.The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis[J].Food and Function,2020,11(6):5205-5222.
[12] 刘萍,赵敏霖,李安润,等.微生态制剂的作用机制及其在奶牛中的应用[J].饲料研究,2022,45(23):134-138.
[13] ARAYA M, MORELLI L, REID G, et al.Guidelines for the evaluation of probiotics in food[R].London, Ontario, Canada:Food and Agriculture Organization of the United Nations/World Health Organization,2002.
[14] KIM S K, GUEVARRA R B, KIM Y T, et al.Role of probiotics in human gut microbiome-associated diseases[J].Journal of Microbiology and Biotechnology,2019,29(9):1335-1340.
[15] DI PIERRO F, PANE M.Bifidobacterium longum W11:uniqueness and individual or combined clinical use in association with rifaximin[J].Clinical Nutrition ESPEN,2021,42:15-21.
[16] WIEËRS G, VERBELEN V, VAN DEN DRIESSCHE M, et al. Do probiotics during in-hospital antibiotic treatment prevent colonization of gut microbiota with multi-drug-resistant bacteria? a randomized placebo-controlled trial comparing Saccharomyces to a mixture of Lactobacillus, Bifidobacterium, and Saccharomyces[J].Frontiers in Public Health,2021,8:578089.
[17] SÁNCHEZ B, DELGADO S, BLANCO-MÍGUEZ A, et al. Probiotics, gut microbiota, and their influence on host health and disease[J].Molecular Nutrition and Food Research,2017,61:1600240.
[18] GIBSON G R, ROBERFROID M B.Dietary modulation of the human colonic microbiota:introducing the concept of prebiotics[J].The Journal of Nutrition,1995,125(6):1401-1412.
[19] REDDY R S, SWAPNA L A, RAMESH T, et al.Bacteria in oral health - probiotics and prebiotics a review[J].International Journal of Biological and Medical Research,2011,2(4):1226-1233.
[20] DAVANI-DAVARI D, NEGAHDARIPOUR M, KARIMZADEH I, et al.Prebiotics:definition, types, sources, mechanisms, and clinical applications[J].Foods,2019,8(3):92.
[21] KUMARI R, SINGH A, YADAV A N, et al.Probiotics, prebiotics, and synbiotics:current status and future uses for human health[M]//RASTEGARI A A,YADAV A,YADAV N.New and Future Developments in Microbial Biotechnology and Bioengineering. Amsterdam:Elsevier,2020:173-190.
[22] THORAKKATTU P, KHANASHYAM A C, SHAH K, et al.Postbiotics:current trends in food and pharmaceutical industry[J].Foods,2022,11(19):3094.
[23] SWANSON K S, GIBSON G R, HUTKINS R, et al.The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics[J].Nature Reviews Gastroenterology and Hepatology,2020,17(11):687-701.
[24] MOHD FUAD A S, AMRAN N A, NASRUDDIN N S, et al. The mechanisms of probiotics, prebiotics, synbiotics, and postbiotics in oral cancer management[J].Probiotics and Antimicrobial Proteins,2023,15(5):1298-1311.
[25] SALMINEN S, COLLADO M C, ENDO A, et al.The International Scientific Association of Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of postbiotics[J].Nature Reviews Gastroenterology and Hepatology,2021,18(9):649-667.
[26] ZÓŁKIEWICZ J, MARZEC A, RUSZCZYNSKI M, et al. Postbiotics:a step beyond pre- and probiotics[J].Nutrients,2020,12(8):2189.
[27] 刘波,敖日格乐,王纯洁,等.复合乳酸菌和酵母菌对新生犊牛免疫和抗氧化功能的影响[J].中国兽医学报,2022,42(2):263-269.
[28] MOHAMADI ROODPOSHTI P, DABIRI N.Effects of probiotic and prebiotic on average daily gain, fecal shedding of Escherichia coli, and immune system status in newborn female calves[J].Asian-Australasian Journal of Animal Sciences,2012,25(9):1255-1261.
[29] ANTANAITIS R, DŽERMEIKAITE K, KRIŠTOLAITYTE J, et al. Effects of Bacillus subtilis on growth performance, metabolic profile, and health status in dairy calves[J].Animals,2024,14(17):2489.
[30] ZHANG R, ZHOU M, TU Y, et al.Effect of oral administration of probiotics on growth performance, apparent nutrient digestibility and stress-related indicators in Holstein calves[J].Journal of Animal Physiology and Animal Nutrition,2016,100(1):33-38.
[31] 钱明珠,王申锋,孙玲利,等.复合微生态制剂对初生犊牛生长性能和血清抗氧化指标的影响[J].中国饲料,2023(8):42-45.
[32] KARAMZADEH-DEHAGHANI A, TOWHIDI A, ZHANDI M, et al.Combined effect of probiotics and specific immunoglobulin Y directed against Escherichia coli on growth performance, diarrhea incidence, and immune system in calves[J].Animal,2021,15(2):100124.
[33] CHANG M N, WANG F F, MA F T, et al.Supplementation with galacto-oligosaccharides in early life persistently facilitates the microbial colonization of the rumen and promotes growth of preweaning Holstein dairy calves[J].Animal Nutrition,2022,10:223-233.
[34] RUVALCABA-GÓMEZ J M, VILLASEÑOR-GONZÁLEZ F, ESPINOSA-MARTÍNEZ M A, et al. Growth performance and fecal microbiota of dairy calves supplemented with autochthonous lactic acid bacteria as probiotics in Mexican western family dairy farming[J].Animals,2023,13(18):2841.
[35] MAAMOURI O, BEN SALEM M.The effect of live yeastSaccharomyces cerevisiaeas probiotic supply on growth performance, feed intake, ruminal pH and fermentation in fattening calves[J].Veterinary Medicine and Science,2022,8(1):398-404.
[36] IKE K A, CASPER D P, HANSEN W P, et al.Milk replacer galacto-oligosaccharide inclusion rates for neonatal calves[J].Journal of Dairy Science,2024,107(12):10667-10679.
[37] GAO Y L, ZHANG W Q, ZHANG T, et al.Fructo-oligosaccharide supplementation enhances the growth of nursing dairy calves while stimulating the persistence of Bifidobacterium and hindgut microbiome′s maturation[J].Journal of Dairy Science,2024,107(8):5626-5638.
[38] SHARMA A N, CHAUDHARY P, KUMAR S, et al.Effect of synbiotics on growth performance, gut health, and immunity status in pre-ruminant buffalo calves[J].Scientific Reports,2023,13:10184.
[39] FROEHLICH K A, ABDELSALAM K W, CHASE C, et al.Evaluation of essential oils and prebiotics for newborn dairy calves[J].Journal of Animal Science,2017,95(8):3772.
[40] DAR A H, SINGH S K, RAHMAN J U, et al.The effects of probiotic Lactobacillus acidophilus and/or prebiotic mannan oligosaccharides on growth performance, nutrient utilization, blood metabolites, faecal bacteria, and economics of crossbred calves[J].Iranian Journal of Veterinary Research,2022,23(4):322-330.
[41] MCKEE A S, MUNKS M W, MARRACK P.How do adjuvants work? Important considerations for new generation adjuvants[J].Immunity,2007,27(5):687-690.
[42] LIU S X, YANG L, ZHANG Y F, et al.Review of yeast culture concerning the interactions between gut microbiota and young ruminant animals[J].Frontiers in Veterinary Science,2024,11:1335765.
[43] KAWAKAMI S I, YAMADA T, NAKANISHI N, et al.Feeding of lactic acid bacteria and yeast affects fecal flora of Holstein calves[J].Journal of Animal and Veterinary Advances,2011,10(3):269-271.
[44] SWEDZINSKI C, FROEHLICH K A, ABDELSALAM K W, et al.Evaluation of essential oils and a prebiotic for newborn dairy calves[J]. Translational animal science,2019(1):75-83.
[45] WU Z Q, REN Y L, LIANG Y J, et al.Synthesis, characterization, immune regulation, and antioxidative assessment of yeast-derived selenium nanoparticles in cyclophosphamide-induced rats[J].ACS Omega,2021,6(38):24585-24594.
[46] LIU T, CHEN H, BAI Y, et al.Calf starter containing a blend of essential oils and prebiotics affects the growth performance of Holstein calves[J].Journal of Dairy Science,2020,103(3):2315-2323.
[47] PI Y, MU C L, GAO K, et al.Increasing the hindgut carbohydrate/protein ratio by cecal infusion of corn starch or casein hydrolysate drives gut microbiota-related bile acid metabolism to stimulate colonic barrier function[J].mSystems,2020,5(3):e00176-20.
[48] LI N, PANG B, LI J J, et al.Mechanisms for Lactobacillus rhamnosustreatment of intestinal infection by drug-resistant Escherichia coli[J].Food and Function,2020,11(5):4428-4445.
[49] YU W N, ZHANG J, CHEN Z W, et al.Inhibitory effect of a microecological preparation on azoxymethane/dextran sodium sulfate-induced inflammatory colorectal cancer in mice[J].Frontiers in Oncology,2020,10:562189.
[50] WEI X S, ZOU J F, ZHANG Y W, et al.Effects of milk, milk replacer, and milk replacer plus ethoxyquin on the growth performance, weaning stress, and the fecal microbiota of Holstein dairy calves[J].Frontiers in Microbiology,2023,14:1113518.
[51] FRIZZO L S, SOTO L P, ZBRUN M V, et al.Lactic acid bacteria to improve growth performance in young calves fed milk replacer and spray-dried whey powder[J].Animal Feed Science and Technology,2010,157(3/4):159-167.
[52] VILLOT C, MA T, RENAUD D L, et al.Saccharomyces cerevisiae boulardii CNCM I-1079 affects health, growth, and fecal microbiota in milk-fed veal calves[J].Journal of Dairy Science,2019,102(8):7011-7025.

Research Progress on the Application of Microecological Preparations in Calf Growth and Development

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	XU Xiaoyi, GAO Feng. Research Progress on the Antioxidant Effects of Bioactive Peptides [J]. Animal Husbandry and Feed Science, 2026, 47(2): 51-56.
[2]	HUANG Yuzhi, HE Hang, HUANG Yulu, XU Lanmeng, YAN Qing, SU Shaofeng, ZHANG Jie. Mechanisms and Application Strategies of Gut Microbiota-Induced Muscle Metabolic Abnormalities in Livestock and Poultry via the Gut-Muscle Axis [J]. Animal Husbandry and Feed Science, 2026, 47(1): 1-8.
[3]	YAN Shuqi¹, ZHAI Manjia¹, CHEN Qiyao¹, YUE Taojing¹, LU Ya′nan¹, WANG Li², HUANG Shucheng¹. Research Progress of Chinese Herbal Medicine to Improve Broilers Bone Health via Osteogenic-Angiogenic Properties [J]. Animal Husbandry and Feed Science, 2025, 46(6): 85-94.
[4]	YIN Kun, TIAN Kaiyue, LIANG Lu, ZHANG Donghui, HUANG Yubo. Research Progress on the Mechanisms of Action and Influencing Factors of Commonly Used Chemical Disinfectants in Livestock and Poultry [J]. Animal Husbandry and Feed Science, 2025, 46(4): 102-109.
[5]	PAN Yang-su, HE Yang, LI Yong-xiang, CAO Zhen-hui, HUANG Ying, AN Qing-cong, ZHANG Chun-yong, ZHAO Su-mei, HU Hong, PAN Hong-bin. Research Prospect in Application of Microecological Preparations in Animal Husbandry [J]. Animal Husbandry and Feed Science, 2023, 44(1): 64-70.
[6]	WANG Na, DAI Ling-li, Wuyuntana, Bilige, ZHAO Shi-hua, Dalaibaolige. Isolation,Identification and Antimicrobial Sensitivity Test of Providencia rettgeri from Calf [J]. Animal Husbandry and Feed Science, 2022, 43(1): 119-123.
[7]	WANG Na, DAI Ling-li, Wuyuntana, Gangtuoya, ZHAO Shi-hua, Dalaibaolige. Isolation,Identification and Antimicrobial Sensitivity Test of Escherichia coli Associated with Calf Diarrhea in Xilin Gol League,Inner Mongolia [J]. Animal Husbandry and Feed Science, 2021, 42(6): 106-111.
[8]	YANG Xian, WEN Hui-ping, LIU Yan-lin, MA Li, WEI Li. A Comparative Study on Growth and Development Rules of Hy-Line Brown Laying Hens and Jingfen No.2 Laying Hens and Their First Egg Qualities [J]. Animal Husbandry and Feed Science, 2021, 42(2): 57-61.
[9]	SHI Kai-yuan, LI Shu-hong, YANG Fan, MI Ya-ling, PENG Hua. Isolation, Identification and Antimicrobial Susceptibility Test of Escherichia coli Isolates Associated with Calf Diarrhea [J]. Animal Husbandry and Feed Science, 2019, 40(12): 95-97.
[10]	. The Pathogenesis and Prevention of Calf Viral Diarrhea [J]. Animal Husbandry and Feed Science, 2018, 39(6): 102-102.
[11]	. Evaluation on Growth Adaptability of Bayannaoer Multiparous Sheep in Korla City of Xinjiang [J]. Animal Husbandry and Feed Science, 2018, 39(5): 16-16.
[12]	. Application of Probiotics in Calf Production [J]. Animal Husbandry and Feed Science, 2018, 39(5): 34-34.
[13]	. Research Progress on Xylo-oligosaccharide and Its Protective Effect on Calf Diarrhea [J]. Animal Husbandry and Feed Science, 2017, 38(7): 53-53.
[14]	. Correlation between Growth and Development of Natural Herbage and Meteorological Condition on the Northern Slope of Central Tianshan Mountains [J]. Animal Husbandry and Feed Science, 2017, 38(6): 48-48.
[15]	. Integration Technology for Improving the Survival Rate of Newborn Calves [J]. Animal Husbandry and Feed Science, 2016, 37(6): 114-114.