Abstract: The weaned piglets diarrhea was a kind of disease that seriously harmed swine industry. The antibiotics abuse had resulted in many problems of producing of drug-resistant bacteria, drop of antibiotics efficacy and residue in livestock products and so on, which greatly limited its application on prevention and treatment to weaned piglets diarrhea. The author summarized the research progress on some medicines that were used easily, in low cost and green environmental protection, and also could effectively prevent and treat weaned piglets diarrhea.