Brachyury基因在胚胎发育过程中的重要作用相关研究进展

doi:10.12160/j.issn.1672-5190.2020.02.004

Abstract

Abstract: Brachyury （T） gene is the first identified gene in the T-box family, hence the name of the gene family was obtained. Scientists have been exploring the molecular structure and physiological functions of Brachyury genes and members of the T-box family. Studies have found that Brachyury gene has high homology in various animal species, which indicates that the T gene is highly conserved during the evolution process. Brachyury gene plays an indispensable role in the formation of notochord, tail buds and allantois during mammalian embryonic development, and the cause of the impediment in embryonic development is most likely the up-regulation or down-regulation of factors related to the Wnt and FGF signaling pathways induced by the changes in the Brachyury gene. Later researches have also found that the formation of the short tail phenotype in animals also seems to be closely associated with the expression of the Brachyury gene during embryonic development. Based on the research status of Brachyury gene at home and abroad, we summarized the homology of Brachyury gene and its regulatory role during embryonic development, in hoping to provide a reference for related researches.

Key words: Brachyury gene, embryonic development, short tail phenotype, research progress

CLC Number:

Q789

SU Hong, ZHI Da-fu, YANG Guang, WANG Tong, TIAN Zhi-peng, CAO Gui-fang. Advances in Research on the Important Role of Brachyury Gene during Embryonic Development[J]. Animal Husbandry and Feed Science, 2020, 41(2): 13-16.

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Advances in Research on the Important Role of Brachyury Gene during Embryonic Development

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