Abstract: With the senior high vocational education thought as instruction,a lot of useful exploration was conducted by carefully selecting excellent contents of microorganism experiments,reasonably arranging order of the experiments,reforming teaching methods of the experiments,and reforming evaluation systems of the microbiological experiments.In the process of the microbiological experiments,attention was paid to enhancing the comprehensive abilities of students such as practical ability and ability to analyze and solve problems and to initiating their interest and enthusiasm in study.Practice has proved that such reform measures can effectively improve teaching quality of the microbiological experiments,which can meet targets of senior high vocational colleges.