Abstract: Agriophyllum squarrosum is a versatile economic plant, which is also used for herbs,edible, forage and bindingsand. Agriophyllum squarrosum is rich in nutrition, pollution-free, as people demand for green food, wild vegetables become the urgent need. We put forward some measures of pollution-free artificial domesticated cultivation of Agriophyllum squarrosum, such as biological characteristics, introductive source, productive technology, fertilizer and water management,pest control and the harvest, storage and transportation of seeds. We provided the direction for standardized cultivation,accordingly, enhancing the yield and improving the quality of Agriophyllum squarrosum.