畜牧与饲料科学 ›› 2011, Vol. 32 ›› Issue (11): 56-56.doi: 10.12160/j.issn.1672-5190.2011.11.027

• 药物科学 • 上一篇    下一篇

中兽药复方“连藤”的抗炎作用及安全性评价

谢丽丽[1] 赵灵颖[2] 胡庭俊[1]   

  1. [1]广西大学动物科学技术学院,广西南宁530005 [2]桂林医学院科学实验中心,广西桂林541004
  • 出版日期:2011-11-20 发布日期:2011-11-20
  • 通讯作者: 谢丽丽
  • 作者简介:谢丽丽(1986-),女。硕士,主要研究方向为中兽药的研究与开发。 通讯作者:胡庭俊(1965-),男,教授,博士,主要研究方向为中兽药的研究与开发。
  • 基金资助:
    广西“新世纪十百千人才工程”专项资金(2006207).

Anti-inflammatory Effect and Safety Evaluation of a Chinese Traditional Veterinary Compound Preparation "Lianteng"

XIE Li-li, ZHAO Ling'ying, HU Ting-jun (1.College of Animal Science and Technology, Guangxi University,Nanning 530005, China; 2. Scientific Research Center, Guilin Medical University, Guilin 541004, China)   

  • Online:2011-11-20 Published:2011-11-20

摘要: 试验选择中草药连翘、青风藤等配伍组成复方制剂“连藤”,采用水煎醇提法提取该复方制刑有效成分,通过急性毒性试验、最大耐受量试验、异常毒性试验对复方“连藤”的安全性进行评价,经二甲苯致小鼠耳廓肿胀试验检测复方“连藤”的抗炎作用。结果表明,复方“连藤”为实际无毒,其最大耐受量为18g/(kg·bw);在体内抗炎试验中,复方“连藤”的高[10.0g/(kg·bw)]、中[5.0g/(kg·bw)]剂量组的肿胀抑制作用明显高于阳性对照(地塞米松)组。复方“连藤”安全、无毒且有良好的抗炎作用,具有开发潜力。

Abstract: The compound preparation "Lianteng" was composed of Chinese herbal medicine Forsythia suspensa (Thunb.)Vahl and Caulis sinomenii. The effective components of this compound preparation were extracted by using water decoction and ethanol extraction method. By acute toxicity test, maximum tolerance test and abnormal toxicity test, the safety of the compound preparation "Lianteng" was evaluated. The anti-inflammatory function of the compound preparation "Lianteng" was detected by using dimethylbenzene-induced auricle-swollen test of mice. The results showed that the compound preparation "Lianteng" was nontoxic and the maximum tolerance dose was 18 g/(kg.bw). In the anti-inflammatory test in vivo, the repression rate of swelling in high dose group [ 10.0 g/(kg.bw) ] and medium dose group [5.0 g/(kg.bw) ] of compound preparation "Lianteng" was obviously higher than that in positive control group (dexamethasone) . The compound preparation "Lianteng" was safe and nontoxic and it had good anti-inflammatory effects and developmental potential .

中图分类号: