Brachyury基因在胚胎发育过程中的重要作用相关研究进展

doi:10.12160/j.issn.1672-5190.2020.02.004

畜牧与饲料科学 ›› 2020, Vol. 41 ›› Issue (2): 13-16.doi: 10.12160/j.issn.1672-5190.2020.02.004

Brachyury基因在胚胎发育过程中的重要作用相关研究进展

苏红^1,2, 智达夫², 杨光², 王彤², 田志鹏³, 曹贵方¹

1.内蒙古农业大学兽医学院,内蒙古呼和浩特 010018;
2.内蒙古自治区基础兽医学重点实验室,内蒙古呼和浩特 010018;
3.内蒙古农业大学生命科学学院,内蒙古呼和浩特 010018

收稿日期:2019-12-31 出版日期:2020-02-29 发布日期:2020-04-10
通讯作者: 曹贵方（1963—）,男,教授,博士,博士生导师,主要研究方向为动物组织胚胎与发育生物学。
作者简介:苏红（1995—）,女,硕士研究生,主要研究方向为动物组织胚胎与发育生物学。
基金资助:
国家自然科学基金项目（3186130045）

Advances in Research on the Important Role of Brachyury Gene during Embryonic Development

SU Hong^1,2, ZHI Da-fu², YANG Guang², WANG Tong², TIAN Zhi-peng³, CAO Gui-fang¹

1.College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;
2.Inner Mongolia Key Laboratory of Basic Veterinary Science,Hohhot 010018,China;
3.College of Life Science, Inner Mongolia Agricultural University,Hohhot 010018,China

Received:2019-12-31 Online:2020-02-29 Published:2020-04-10

摘要/Abstract

摘要： Brachyury（T）基因是T-box家族中第一个被鉴定出来的基因,该家族也因此得名。科学家们一直在探索Brachyury基因和T-box家族各成员的分子结构和生理功能,研究发现,Brachyury基因在多种动物中同源性都比较高,这说明T基因在进化过程中高度保守;Brachyury基因在哺乳动物胚胎发育过程中对脊索、尾芽和尿囊的形成起到不可或缺的作用,而导致胚胎发育出现障碍的原因极有可能是Brachyury基因的改变引起了与Wnt和FGF信号通路相关因子表达的上调或下调;后来的研究还发现,动物短尾表型的形成似乎也与Brachyury基因在胚胎发育期间的表达有密切关系。基于国内外对Brachyury基因的研究现状,对Brachyury基因同源性和其在胚胎发育期间所起到的调控作用进行整理归纳,以期为相关研究提供参考。

关键词: Brachyury基因, 胚胎发育, 短尾表型, 研究进展

Abstract: Brachyury （T） gene is the first identified gene in the T-box family, hence the name of the gene family was obtained. Scientists have been exploring the molecular structure and physiological functions of Brachyury genes and members of the T-box family. Studies have found that Brachyury gene has high homology in various animal species, which indicates that the T gene is highly conserved during the evolution process. Brachyury gene plays an indispensable role in the formation of notochord, tail buds and allantois during mammalian embryonic development, and the cause of the impediment in embryonic development is most likely the up-regulation or down-regulation of factors related to the Wnt and FGF signaling pathways induced by the changes in the Brachyury gene. Later researches have also found that the formation of the short tail phenotype in animals also seems to be closely associated with the expression of the Brachyury gene during embryonic development. Based on the research status of Brachyury gene at home and abroad, we summarized the homology of Brachyury gene and its regulatory role during embryonic development, in hoping to provide a reference for related researches.

Key words: Brachyury gene, embryonic development, short tail phenotype, research progress

中图分类号:

Q789

苏红, 智达夫, 杨光, 王彤, 田志鹏, 曹贵方. Brachyury基因在胚胎发育过程中的重要作用相关研究进展[J]. 畜牧与饲料科学, 2020, 41(2): 13-16.

SU Hong, ZHI Da-fu, YANG Guang, WANG Tong, TIAN Zhi-peng, CAO Gui-fang. Advances in Research on the Important Role of Brachyury Gene during Embryonic Development[J]. Animal Husbandry and Feed Science, 2020, 41(2): 13-16.

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Brachyury基因在胚胎发育过程中的重要作用相关研究进展

Advances in Research on the Important Role of Brachyury Gene during Embryonic Development

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