腺苷酸活化蛋白激酶在奶牛疾病中的作用研究进展

doi:10.12160/j.issn.1672-5190.2022.06.002

畜牧与饲料科学 ›› 2022, Vol. 43 ›› Issue (6): 6-13.doi: 10.12160/j.issn.1672-5190.2022.06.002

腺苷酸活化蛋白激酶在奶牛疾病中的作用研究进展

窦文丽¹,宝华²,曹佩佩¹,孙奕烁¹,刘吉国³,杨文飞³,马云¹,马燕芬^1,²

1.宁夏大学农学院/宁夏回族自治区反刍动物分子细胞育种重点实验室，宁夏银川 750021
2.内蒙古自治区农牧业科学院动物营养与饲料研究所，内蒙古呼和浩特 010031
3.宁夏新澳农牧有限公司，宁夏灵武 750406

收稿日期:2022-10-03 出版日期:2022-11-30 发布日期:2022-12-19
通讯作者: 马燕芬（1979—），女，研究员，博士，博士生导师，主要从事奶牛营养调控理论与技术研究工作。
作者简介:窦文丽（1999—），女，硕士研究生，主要研究方向为动物营养调控与免疫。
基金资助:
宁夏自然科学基金项目(2022AAC02006);内蒙古自治区科技计划项目(2021GG0025);内蒙古自然科学基金项目(2021MS03068);宁夏回族自治区乡村振兴科技成果引进示范推广项目(2021CGSF0206);银川市科技计划项目(2022XQ008)

Research Progress on Roles of AMP-activated Protein Kinase in Dairy Cow Diseases

DOU Wen-li¹,Baohua ²,CAO Pei-pei¹,SUN Yi-shuo¹,LIU Ji-guo³,YANG Wen-fei³,MA Yun¹,MA Yan-fen^1,²

1. School of Agriculture，Ningxia University/Key Laboratory of Ruminant Molecular and Cellular Breeding of Ningxia Hui Autonomous Region，Yinchuan 750021，China
2. Institute of Animal Nutrition and Feed，Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences，Hohhot 010031，China
3. Ningxia Xin′ao Agriculture and Animal Husbandry Co.，Ltd.，Lingwu 750406，China

Received:2022-10-03 Online:2022-11-30 Published:2022-12-19

摘要/Abstract

摘要：

随着奶牛养殖规模化、集约化程度的不断提高，奶牛养殖过程中乳腺炎、酮病和脂肪肝等疾病的发病率也逐年增加。腺苷酸活化蛋白激酶（AMP-activated protein kinase，AMPK）作为一种能量感受器可以反映细胞能量状态。AMPK在葡萄糖、脂质和蛋白质代谢以及线粒体生物发生和自噬等过程中发挥重要调控作用。AMPK被认为是多种疾病潜在的干预或治疗靶点，在奶牛代谢性疾病中的研究也较为广泛。综述了AMPK在奶牛乳腺炎、酮病、脂肪肝中的调控作用研究进展，以期为这些疾病的靶向治疗提供参考。

关键词: 腺苷酸活化蛋白激酶, 乳腺炎, 脂肪肝, 酮病, 乳脂合成

Abstract:

The incidence of mastitis, ketosis, fatty liver and some other diseases in dairy cow farming has increased year after year as large-scale and intensive dairy cow farming improved. As an energy receptor, AMP-activated protein kinase （AMPK） reflects the energy state of cells. AMPK plays crucial roles in glucose, lipid and protein metabolism as well as in mitochondrial biogenesis and autophagy. AMPK is thought to be a potential intervention or treatment target for a variety of diseases and has been extensively studied in metabolic diseases of dairy cows. This paper reviews the research progress on regulative roles of AMPK in dairy cow mastitis, ketosis and fatty liver, in hoping to provide references for targeted treatment of these diseases.

Key words: AMP-activated protein kinase, mastitis, fatty liver, ketosis, milk fat synthesis

中图分类号:

S858.232.2

窦文丽, 宝华, 曹佩佩, 孙奕烁, 刘吉国, 杨文飞, 马云, 马燕芬. 腺苷酸活化蛋白激酶在奶牛疾病中的作用研究进展[J]. 畜牧与饲料科学, 2022, 43(6): 6-13.

DOU Wen-li, Baohua , CAO Pei-pei, SUN Yi-shuo, LIU Ji-guo, YANG Wen-fei, MA Yun, MA Yan-fen. Research Progress on Roles of AMP-activated Protein Kinase in Dairy Cow Diseases[J]. Animal Husbandry and Feed Science, 2022, 43(6): 6-13.

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腺苷酸活化蛋白激酶在奶牛疾病中的作用研究进展

Research Progress on Roles of AMP-activated Protein Kinase in Dairy Cow Diseases

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