FABPs基因家族在动物育种领域的研究进展

doi:10.12160/j.issn.1672-5190.2023.06.009

摘要/Abstract

摘要： 脂肪酸结合蛋白（fatty acid binding proteins,FABPs）广泛存在于动物组织中,通过调节细胞内脂肪酸的转运代谢影响细胞分化,在机体的炎症调节与免疫代谢中也发挥至关重要的作用。研究FABPs基因家族与畜禽表型的关联性对于提高畜禽个体经济价值具有重要意义。介绍了FABPs基因家族成员的主要功能及在动物组织器官中的分布情况,综述了该基因家族代表性成员H-FABP基因和A-FABP基因在畜禽育种领域的研究进展,以期为利用该基因家族开展畜禽分子标记辅助育种、改善畜禽生产性状提供参考。

关键词: FABPs基因家族, 脂肪酸, 胴体, 育种, 畜禽

Abstract: Fatty acid binding proteins （FABPs） are widely present in animal tissues and affect cell differentiation by regulating the transport and metabolism of intracellular fatty acid. They also play a crucial role in inflammation regulation and immune metabolism in the body. Unveiling the association between the FABPs gene family and animal phenotype is of great significance for improving the individual economic value of livestock and poultry. This article introduces the main functions of the FABPs gene family members and their distribution in animal tissues and organs, reviews the research progress of representative members of the gene family, H-FABP gene and A-FABP gene, in the field of livestock and poultry breeding, in hoping to provide references for using this gene family to conduct molecular marker assisted breeding and to improve livestock and poultry production traits.

Key words: FABPs gene family, fatty acid, carcass, breeding, livestock and poultry

中图分类号:

S813.2

林彭楚彬, 孙三山, 高亚杰, 阮超, 严杜建. FABPs基因家族在动物育种领域的研究进展[J]. 畜牧与饲料科学, 2023, 44(6): 76-81.

LIN-PENG Chubin, SUN Sanshan, GAO Yajie, RUAN Chao, YAN Dujian. Research Progress of FABPs Gene Family in Animal Breeding[J]. Animal Husbandry and Feed Science, 2023, 44(6): 76-81.

参考文献

[1] 王慧,郑立,文逸凡,等.动物FABP基因家族研究进展及育种应用探讨[J].基因组学与应用生物学,2018,37(12):5275-5280.
[2] WANG Z, YUE Y X, LIU Z M, et al.Genome-wide analysis of the FABP gene family in liver of chicken (Gallus gallus):Identification, dynamic expression profile, and regulatory mechanism[J].International Journal of Molecular Sciences,2019,20(23):5948.
[3] 刘顺德,李娜,高小艳,等.动物FABP家族基因与脂肪沉积关联研究进展[J].农业科学研究,2010,31(3):44-48.
[4] LI B, HAO J Q, ZENG J, et al.SnapShot: FABP functions[J].Cell,2020,182(4):1066-1066.
[5] 高妍,张永宏,李毅,等.脂肪酸结合蛋白研究进展[J].动物医学进展,2007,28(1):64-67.
[6] ONO T.Studies of the FABP family: A retrospective[J].Molecular and Cellular Biochemistry,2005,277(1):1-6.
[7] MA H K, GAO H, XU W Y, et al.Cloning and functional study of fatty acid-binding protein-like gene of the ridgetail white prawn, Exopalaemon carinicauda[J].Aquaculture International,2020,28(4):1517-1530.
[8] KARANTH S, DENOVAN-WRIGHT E M, THISSE C, et al. The evolutionary relationship between the duplicated copies of the zebrafish fabp11 gene and the tetrapod FABP4, FABP5, FABP8 and FABP9 genes[J].The FEBS Journal,2008,275(12):3031-3040.
[9] GERBENS F, VERBURG F J, VAN MOERKERK H T B, et al. Associations of heart and adipocyte fatty acid-binding protein gene expression with intramuscular fat content in pigs[J].Journal of Animal Science,2001,79(2):347-354.
[10] MAO H G, XU X L, CAO H Y, et al.H-FABP gene expression and genetic association with meat quality traits in domestic pigeons (Columba livia)[J].British Poultry Science,2021,62(2):172-179.
[11] 曹健. 牦牛A-FABP、H-FABP基因多态性及与胴体和肉质性状关联性分析[D].兰州:甘肃农业大学,2012.
[12] 刘艳妍. 牛A-FABP基因的多态性及其与秦川牛肉用性状的关联分析[D].杨凌:西北农林科技大学,2010.
[13] CHO S, PARK T S, YOON D H, et al.Identification of genetic polymorphisms in FABP3 and FABP4 and putative association with back fat thickness in Korean native cattle[J].Biochemistry and Molecular Biology,2008,41(1):29-34.
[14] YIN B Z, FANG J C, ZHANG J S, et al.Correlations between single nucleotide polymorphisms in FABP4 and meat quality and lipid metabolism gene expression in Yanbian yellow cattle[J].PLoS One,2020,15(6):e0234328.
[15] MENTARI A S, GUNAWAN A, NOOR R R.Polymorphism of L-FABP (SNP g. 1593 C>T) gene and its association with fatty acid composition, carcass, and meat quality in Cihateup duck[J].Tropical Animal Science Journal,2020,43(2):103-109.
[16] WANG Q, LI H, LI N, et al.Tissue expression and association with fatness traits of liver fatty acid-binding protein gene in chicken[J].Poultry Science,2006,85(11):1890-1895.
[17] KOOPAEI H K, KOSHKOIYEH A E.Application of genomic technologies to the improvement of meat quality of farm animals[J].Meat Science,2007,77(1):36-45.
[18] LEVY E, MÉNARD D, DELVIN E, et al. Localization, function and regulation of the two intestinal fatty acid-binding protein types[J].Histochemistry and Cell Biology,2009,132(3):351-367.
[19] NIEWOLD T A, MEINEN M, VAN DER MEULEN J. Plasma intestinal fatty acid binding protein (Ⅰ-FABP) concentrations increase following intestinal ischemia in pigs[J].Research in Veterinary Science,2004,77(1):89-91.
[20] CAHYANINGSIH U, SATYANINGTIJAS A S, TARIGAN R, et al.Chicken Ⅰ-FABP as biomarker of chicken intestinal lesion caused by coccidiosis[J].IOP Conference Series:Earth and Environmental Science,2018,196:012032.
[21] HER G M, CHIANG C C, WU J L.Zebrafish intestinal fatty acid binding protein (Ⅰ-FABP) gene promoter drives gut-specific expression in stable transgenic fish[J].Genesis,2004,38(1):26-31.
[22] GUGLIELMO C G.Physiological and biochemical modulation for long-distance migration: The functional significance of intraspecific variation in the western sandpiper[D].Vancouver:Simon Fraser University,2001.
[23] 崔璐,陈星,周颖,等.FABPs家族基因的研究进展[J].畜牧与兽医,2016,48(7):128-131.
[24] 杨霞. 鸡Ex-FABP基因单核苷酸多态性及其与脂肪性状的相关研究[D].雅安:四川农业大学,2006.
[25] YANG X F, XU S G, LI W T, et al.The expression of brain-type fatty acid binding protein (FABP7) in rainbow trout (Oncorhynchus mykiss)[C]//Association for Computing Machinery(ACM). Proceedings of the 2018 10^th International Conference on Bioinformatics and Biomedical Technology. New York:ACM,2018:33-36.
[26] PRENTICE K J, SAKSI J, ROBERTSON L T, et al.A hormone complex of FABP4 and nucleoside kinases regulates islet function[J].Nature,2021,600(7890):720-726.
[27] 王卓,昝林森.秦川牛H-FABP基因第1外显子SNP及其与部分肉用性状相关性的研究[J].西北农林科技大学学报(自然科学版),2008,36(11):11-15.
[28] YE T Z, SHAUKAT A, YANG L, et al.Evolutionary and association analysis of buffalo FABP family genes reveal their potential role in milk performance[J].Genes,2022,13(4):600.
[29] ARDICLI S, SAMLI H, VATANSEVER B, et al.Comprehensive assessment of candidate genes associated with fattening performance in Holstein-Friesian bulls[J].Archives Animal Breeding,2019,62(1):9-32.
[30] AL-JANABI H R A. Study of some reproductive efficiency indicators of Holstein cows from FABP3 gene polymorphism[J].Biochemical and Cellular Archives,2019,19(1):1109-1115.
[31] IBRAHIM A H M, TZANIDAKIS N, SOTIRAKI S, et al. Identification of the association between FABP4 gene polymorphisms and milk production traits in Sfakia sheep[J].Archives Animal Breeding,2019,62(2):413-422.
[32] EER H H, MA L N, XIE X L, et al.Genetic polymorphism association analysis of SNPs on the species conservation genes of Tan sheep and Hu sheep[J].Tropical Animal Health and Production,2020,52(3):915-926.
[33] 艾锦新,龙安炬,罗卫星,等.黔北麻羊FABP3基因多态性及其与生长性状的相关性研究[J].畜牧与兽医,2021,53(1):13-18.
[34] 热依拉·普拉提,黄李勇,赵雄,等.巴什拜羊A-FABP、PBDC1基因多态性及其与巴什拜羊生长性状的相关分析[J].草食家畜,2018(6):8-16.
[35] TYRA M, ROPKA-MOLIK K, ECKERT R, et al.H-FABP and LEPR gene expression profile in skeletal muscles and liver during ontogenesis in various breeds of pigs[J].Domestic Animal Endocrinology,2011,40(3):147-154.
[36] SHANG P, ZHANG B, ZHANG J, et al.Expression and single-nucleotide polymorphisms of the H-FABP gene in pigs[J].Gene,2019,710:156-160.
[37] ZHU C, WANG L, NIE X Y, et al.Dietary dibutyryl cAMP supplementation regulates the fat deposition in adipose tissues of finishing pigs via cAMP/PKA pathway[J].Animal Biotechnology,2023,34(4):921-934.
[38] WANG Y, LIU W Q, HANG C, et al.Association of A-FABP gene polymorphism and mRNA expression with intramuscular fat content (IMF) in Baicheng-You chicken[J].Journal of Animal Physiology and Animal Nutrition,2019,103(5):1447-1452.
[39] MCKILLOP I H, GIRARDI C A, THOMPSON K J.Role of fatty acid binding proteins (FABPs) in cancer development and progression[J].Cellular Signalling,2019,62:109336.
[40] 钱成,罗卫星,黄兰,等.H-FABP基因在临床医学和畜牧生产上应用研究进展[J].基因组学与应用生物学,2015,34(7):1534-1540.
[41] ZALEWSKA M, PUPPEL K, SAKOWSKI T.Associations between gene polymorphisms and selected meat traits in cattle-A review[J].Animal Bioscience,2021,34(9):1425-1438.